Resveratrol promotes osteogenesis and alleviates osteoporosis by inhibiting p53
Open Access
- 27 May 2020
- journal article
- research article
- Published by Impact Journals, LLC in Aging
- Vol. 12 (11), 10359-10369
- https://doi.org/10.18632/aging.103262
Abstract
Although osteoporosis is one of the most common chronic age-related diseases, there is currently no gold standard for treatment. Evidence suggests resveratrol, a natural polyphenolic compound, may be helpful in the treatment of osteoporosis and other diseases. However, the molecular mechanisms underlying the anti-osteoporotic effects of resveratrol remain largely unknown. In the present study, KEGG pathway enrichment analysis of resveratrol-targeted genes identified 33 associated pathways, 12 of which were also involved in osteoporosis. In particular, the MDM2/p53 signaling pathway was identified as a potential key pathway among the shared pathways. In vitro experiments indicated that MDM2-mediated p53 degradation induced osteoblast differentiation, and resveratrol could partially reverse p53-dependent inhibition of osteogenic differentiation. These findings suggest resveratrol may alleviate osteoporosis at least in part by modulating the MDM2/p53 signaling pathway.Keywords
This publication has 25 references indexed in Scilit:
- Protective effects of resveratrol on postmenopausal osteoporosis: regulation of SIRT1-NF-κB signaling pathwayActa Biochimica et Biophysica Sinica, 2014
- circlizeimplements and enhances circular visualization in RBioinformatics, 2014
- Distinct Rayleigh Scattering from Hot Spot Mutant p53 Proteins Reveals Cancer CellsSmall, 2014
- Osteogenic effects of resveratrol in vitro: potential for the prevention and treatment of osteoporosisAnnals of the New York Academy of Sciences, 2013
- Synergism between resveratrol and other phytochemicals: Implications for obesity and osteoporosisMolecular Nutrition & Food Research, 2011
- Anti‐inflammatory effects of resveratrol: possible role in prevention of age‐related cardiovascular diseaseAnnals of the New York Academy of Sciences, 2011
- Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesNature Protocols, 2008
- Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene listsNucleic Acids Research, 2008
- Epidemiology and outcomes of osteoporotic fracturesThe Lancet, 2002
- Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from GrapesScience, 1997