COVID-19 associated central nervous system manifestations, mental and neurological symptoms: a systematic review and meta-analysis
- 18 December 2020
- journal article
- review article
- Published by Walter de Gruyter GmbH in Progress in Neurobiology
- Vol. 32 (3), 351-361
- https://doi.org/10.1515/revneuro-2020-0108
Abstract
The ongoing pandemic of Coronavirus disease 2019 (COVID-19) has infected more than 27 million confirmed cases and 8,90,000 deaths all around the world. Verity of viral infections can infect the nervous system; these viral infections can present a wide range of manifestation. The aim of the current study was to systematically review the COVID-19 associated central nervous system manifestations, mental and neurological symptoms. For that we conducted a comprehensive systematic literature review of four online databases, including Web of Science, PubMed, Scopus and Embase. All relevant articles that reported psychiatric/psychological symptoms or disorders in COVID-19 without considering time and language restrictions were assessed. All the study procedures were performed based on the PRISMA criteria. Due to the screening, 14 studies were included. The current study result indicated that, the pooled prevalence of CNS or mental associated disorders with 95% CI was 50.68% (6.68–93.88). The most prevalence symptoms were hyposmia/anosmia/olfactory dysfunction (number of study: 10) with 36.20% (14.99–60.51). Only one study reported numbness/paresthesia and dysphonia. Pooled prevalence of numbness/paresthesia and dysphonia was 5.83% (2.17–12.25) and 2.39% (10.75–14.22). The pooled prevalence of depression and anxiety was 3.52% (2.62–4.54) and 13.92% (9.44–19.08). Our findings demonstrate that COVID-19 has a certain relation with neurological symptoms. The hypsomia, anosmia or olfactory dysfunction was most frequent symptom. Other symptoms were headache or dizziness, dysgeusia or ageusia, dysphonia and fatigue. Depression, anxiety, and confusion were less frequent symptoms.Funding Information
- Tehran University of Medical Sciences (50001)
This publication has 76 references indexed in Scilit:
- Respiratory Syncytial Virus Binds and Undergoes Transcription in Neutrophils From the Blood and Airways of Infants With Severe BronchiolitisThe Journal of Infectious Diseases, 2011
- Bronchiolitis-associated encephalopathy in critically-ill infants: An underestimated complication?The Journal of Maternal-Fetal & Neonatal Medicine, 2010
- Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysisThe Lancet, 2010
- Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegenerationProceedings of the National Academy of Sciences of the United States of America, 2009
- The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and ElaborationPLoS Medicine, 2009
- Guillain‐Barré Syndrome and Influenza Virus InfectionClinical Infectious Diseases, 2009
- Pathology of human influenza revisitedVaccine, 2008
- Pathogenesis and Diagnosis of Viral Infections of the Nervous SystemNeurologic Clinics, 2008
- Detection of SARS Coronavirus RNA in the Cerebrospinal Fluid of a Patient with Severe Acute Respiratory SyndromeClinical Chemistry, 2003
- Neurological, Electroencephalographic, and Virological Findings in Febrile ChildrenArchives of Disease in Childhood, 1970