“Get with the Guidelines Heart Failure Risk Score” for mortality prediction in patients undergoing MitraClip
Open Access
- 31 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Clinical Research in Cardiology
- Vol. 110 (12), 1871-1880
- https://doi.org/10.1007/s00392-021-01804-3
Abstract
Background Reliable risk scores in patients undergoing transcatheter edge-to-edge mitral valve repair (TMVR) are lacking. Heart failure is common in these patients, and risk scores derived from heart failure populations might help stratify TMVR patients. Methods Consecutive patients from three Heart Centers undergoing TMVR were enrolled to investigate the association of the “Get with the Guidelines Heart Failure Risk Score” (comprising the variables systolic blood pressure, urea nitrogen, blood sodium, age, heart rate, race, history of chronic obstructive lung disease) with all-cause mortality. Results Among 815 patients with available data 177 patients died during a median follow-up time of 365 days. Estimated 1-year mortality by quartiles of the score (0–37; 38–42, 43–46 and more than 46 points) was 6%, 10%, 23% and 30%, respectively (p < 0.001), with good concordance between observed and predicted mortality rates (goodness of fit test p = 0.46). Every increase of one score point was associated with a 9% increase in the hazard of mortality (95% CI 1.06–1.11%, p < 0.001). The score was associated with long-term mortality independently of left ventricular ejection fraction, NYHA class and NTproBNP, and was equally predictive in primary and secondary mitral regurgitation. Conclusion The “Get with the Guidelines Heart Failure Risk Score” showed a strong association with mortality in patients undergoing TMVR with additive information beyond traditional risk factors. Given the routinely available variables included in this score, application is easy and broadly possible. Graphic abstractKeywords
Funding Information
- Projekt DEAL
This publication has 26 references indexed in Scilit:
- Randomized Comparison of Percutaneous Repair and Surgery for Mitral RegurgitationJournal of the American College of Cardiology, 2015
- One-year outcomes and predictors of mortality after MitraClip therapy in contemporary clinical practice: results from the German transcatheter mitral valve interventions registryEuropean Heart Journal, 2015
- Validation of the Get With The Guideline–Heart Failure risk score in Japanese patients and the potential improvement of its discrimination ability by the inclusion of B-type natriuretic peptide levelAmerican Heart Journal, 2015
- Acute and Midterm Outcome After MitraClip Therapy in Patients With Severe Mitral Regurgitation and Left Ventricular DysfunctionThe American Journal of Cardiology, 2015
- Comparison of Three Contemporary Surgical Scores for Predicting All-Cause Mortality of Patients Undergoing Percutaneous Mitral Valve Repair With the MitraClip System (from the Multicenter GRASP-IT Registry)The American Journal of Cardiology, 2014
- Percutaneous Mitral Valve Edge-to-Edge RepairJournal of the American College of Cardiology, 2014
- Percutaneous Mitral Valve Interventions in the Real World: Early and 1-Year Results From the ACCESS-EU, A Prospective, Multicenter, Nonrandomized Post-Approval Study of the MitraClip Therapy in EuropeJournal of the American College of Cardiology, 2013
- Validated, Electronic Health Record Deployable Prediction Models for Assessing Patient Risk of 30-Day Rehospitalization and Mortality in Older Heart Failure PatientsJACC: Heart Failure, 2013
- A Validated Risk Score for In-Hospital Mortality in Patients With Heart Failure From the American Heart Association Get With the Guidelines ProgramCirculation: Cardiovascular Quality and Outcomes, 2010
- Predicting Mortality Among Patients Hospitalized for Heart FailureJAMA, 2003