A Case of Pediatric Subcutaneous Abscess Caused by Mycobacterium mageritense Infection
- 31 July 2021
- journal article
- research article
- Published by Editorial Committee of Japanese Journal of Infectious Diseases, National Institute of Infectious Dis in Japanese Journal of Infectious Diseases
- Vol. 74 (4), 377-380
- https://doi.org/10.7883/yoken.jjid.2020.621
Abstract
Soft-tissue infection with Mycobacterium mageritense is uncommon. We present the case of a 5-year-old girl who developed soft-tissue infection with M. mageritense in a subcutaneous abscess in her right ankle. She had a history of acute encephalopathy and adrenal insufficiency and was hospitalized for acute pancreatitis. During hospitalization, she developed fever and tachycardia. A blood culture was positive for gram-positive bacilli. Initially, matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) reported a different organism, but a repeat test identified M. mageritense. One month after the positive blood culture, redness and swelling appeared in her right ankle. Drainage from the subcutaneous abscess again grew M. mageritense, which was also confirmed by sequencing of housekeeping genes. Based on a sensitivity test, she was treated with tosufloxacin and linezolid. After starting treatment, local inflammatory findings gradually improved. Antibiotic treatment was completed in 6 months, and she has experienced no relapse in the 8 months since the completion of therapy. This first case report of pediatric M. mageritense infection highlights an important potential pitfall of MALDI-TOF MS. We also report that the choice of antimicrobials for treatment of M. mageritense may be more limited in children than that for adults.Keywords
This publication has 13 references indexed in Scilit:
- 2018 Infectious Diseases Society of America Clinical Practice Guideline for the Management of Outpatient Parenteral Antimicrobial TherapyClinical Infectious Diseases, 2018
- Accuracy of Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry for Identification of Mycobacteria: a systematic review and meta-analysisScientific Reports, 2018
- Implantable cardioverter defibrillator infection due to Mycobacterium mageritenseJournal of Infection and Chemotherapy, 2015
- Dermatitis by Dermatophilus congolensisClinical Microbiology & Infection, 2015
- Potential Pitfalls in MALDI-TOF MS Analysis of Abiotically Synthesized RNA OligonucleotidesOrigins of Life and Evolution of Biospheres, 2013
- Risks associated with the therapeutic use of fluoroquinolonesExpert Opinion on Drug Safety, 2013
- MALDI-TOF mass spectrometry tools for bacterial identification in clinical microbiology laboratoryClinical Biochemistry, 2011
- Cohort Study of Molecular Identification and Typing of Mycobacterium abscessus, Mycobacterium massiliense , and Mycobacterium bolletiiJournal of Clinical Microbiology, 2009
- Clinical and Laboratory Features of Mycobacterium mageritenseJournal of Clinical Microbiology, 2002
- Mycobacterium mageritense sp. nov.International Journal of Systematic and Evolutionary Microbiology, 1997