Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma
Open Access
- 1 February 2021
- Vol. 10 (2), 295
- https://doi.org/10.3390/cells10020295
Abstract
Glaucoma is a leading cause of blindness worldwide. In glaucoma, a progressive dysfunction and death of retinal ganglion cells occurs, eliminating transfer of visual information to the brain. Currently, the only available therapies target the lowering of intraocular pressure, but many patients continue to lose vision. Emerging pre-clinical and clinical evidence suggests that metabolic deficiencies and defects may play an important role in glaucoma pathophysiology. While pre-clinical studies in animal models have begun to mechanistically uncover these metabolic changes, some existing clinical evidence already points to potential benefits in maintaining metabolic fitness. Modifying diet and exercise can be implemented by patients as an adjunct to intraocular pressure lowering, which may be of therapeutic benefit to retinal ganglion cells in glaucoma.Keywords
Funding Information
- Vetenskapsrådet (2018-02124)
This publication has 207 references indexed in Scilit:
- Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) dietsEuropean Journal of Clinical Nutrition, 2013
- NMNAT1 mutations cause Leber congenital amaurosisNature Genetics, 2012
- Real-World Assessment of Physical Activity in Glaucoma Using an AccelerometerOphthalmology, 2012
- Glycolytic oligodendrocytes maintain myelin and long-term axonal integrityNature, 2012
- Primary open-angle glaucoma genesEye, 2011
- Anthropometric Measures and their Relation to Incident Primary Open-Angle GlaucomaOphthalmology, 2010
- PARP inhibition: PARP1 and beyondNature Reviews Cancer, 2010
- Lifestyle, Nutrition, and GlaucomaJournal of Glaucoma, 2009
- Supply and Demand in Cerebral Energy Metabolism: The Role of Nutrient TransportersJournal of Cerebral Blood Flow & Metabolism, 2007
- Obesity and Eye DiseasesSurvey of Ophthalmology, 2007