Variability in hair gadolinium concentrations among decedents who received gadolinium-based contrast agents
- 27 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Analytical and Bioanalytical Chemistry
- Vol. 413 (6), 1571-1582
- https://doi.org/10.1007/s00216-020-03116-3
Abstract
This study utilized laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) to quantify gadolinium in the hair of autopsy cases that had received gadolinium-based contrast agents (GBCAs) before death. Consecutive autopsy cases were reviewed for GBCA injections and subjects who received a single type of GBCA in the year before death were included. Hair samples were analyzed using LA-ICP-MS as a line scan technique and parameters were optimized to maximize instrument sensitivity, accuracy, and precision. Linear regression analyses between hair measures and gadolinium dose were executed. LA-ICP-MS analysis produced a time-resolved record of GCBA exposure, with the position of the gadolinium peak maxima along the hair shaft providing a good estimate for the day that GBCA injection occurred (R2 = 0.46; p = 0.0022); however, substantial within and between subject variation in the position of the GBCA peak was observed. Average area under the curve for gadolinium peaks in the hair samples was a better predictor of gadolinium dose (R2 = 0.41; p = 0.0046), compared to the average of peak maxima concentration. Correlation between area under the curve and dose suggests that LA-ICP-MS analysis of hair may be an effective method to evaluate gadolinium levels in subjects in vivo after exposure to GBCAs. This study demonstrates that analysis of human hair using techniques with high spatial resolution such as LA-ICP-MS has excellent potential to reveal time-dependent signatures of past exposures.Keywords
Funding Information
- Guerbet, LLC
- National Institute of Environmental Health Sciences (P30ES007033)
This publication has 53 references indexed in Scilit:
- The effect of sebocytes cultured from nevus sebaceus on hair growthExperimental Dermatology, 2012
- Relationships between hair growth rate and morphological parameters of human straight hair: a same law above ethnical origins?International Journal of Cosmetic Science, 2011
- Assessment of Pharmacologic Area Under the Curve When Baselines are VariablePharmaceutical Research, 2011
- Metal doped keratin film standard for LA-ICP-MS determination of lead in hair samplesJournal of Analytical Atomic Spectrometry, 2010
- Biomonitoring of essential and toxic metals in single hair using on-line solution-based calibration in laser ablation inductively coupled plasma mass spectrometryTalanta, 2010
- The hair cycleJournal of Cell Science, 2006
- Direct detection of mercury in single human hair strands by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)Journal of Analytical Atomic Spectrometry, 2004
- The spatial resolution of LA-ICP-MS line scans across heterogeneous materials such as fish otoliths and zoned mineralsJournal of Analytical Atomic Spectrometry, 2003
- Application of double focusing sector field ICP-MS for multielemental characterization of human hair and nails. Part III. Direct analysis by laser ablationScience of The Total Environment, 2003
- Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) for the multielemental analysis of biological materials: a feasibility studyFood Chemistry, 1994