Child-Onset Infectious Mononucleosis Complicated with Hypogammaglobulinemia, Polyserous Effusions and Orchitis: A Case Report

Abstract

对青岛大学附属烟台毓璜顶医院儿内科收治的1例传染性单核细胞增多症合并低丙种球蛋白血症、多浆膜腔积液及睾丸炎患儿的临床资料进行回顾性分析。传染性单核细胞增多症症状及实验室检查可不典型，对于发热伴皮疹、肝功能异常合并浆膜腔积液及睾丸炎患儿应警惕EB病毒感染可能，对于EB病毒感染伴低丙种球蛋白血症患儿应警惕普通变异型免疫缺陷病(CVID)可能，入院时应及时完善免疫缺陷病相关基因检测，对基因检测阴性患儿仍要长期随访。 The clinical data of a case of infectious mononucleosis complicated with hypogammaglobulinemia, polyserous effusions and orchitis in the pediatric department of the Affiliated Yantai Yuhuangding Hospital of Qingdao University were retrospectively analyzed. Infectious mononucleosis symptoms and laboratory tests are not typical; for children with fever accompanied by a rash, abnormal liver function with serous cavity effusion and orchitis, the possibility of Epstein-Barr virus (EBV) infection should be vigilant; children with Epstein-Barr virus infection with hypogammaglobulinemia should be alert to the possibility of common variant immunodeficiency disease (CVID). Immunodeficiency disease related gene testing should be improved in time upon admission, and long-term follow-up should still be conducted for children with negative gene testing.