Stem cell‐based therapies for cardiac diseases: The critical role of angiogenic exosomes
- 19 February 2021
- journal article
- review article
- Published by Wiley in BioFactors
- Vol. 47 (3), 270-291
- https://doi.org/10.1002/biof.1717
Abstract
Finding effective treatments for cardiac diseases is among the hottest subjects in medicine; cell‐based therapies have brought great promises for managing a broad range of life‐threatening heart complications such as myocardial infarction. After clarifying the critical role of angiogenesis in tissue repair and regeneration, various stem/progenitor cell were utilized to accelerate the healing of injured cardiac tissue. Embryonic, fetal, adult, and induced pluripotent stem cells have shown the appropriate proangiogenic potential for tissue repair strategies. The capability of stem cells for differentiating into endothelial lineages was initially introduced as the primary mechanism involved in improving angiogenesis and accelerated heart tissue repair. However, recent studies have demonstrated the leading role of paracrine factors secreted by stem cells in advancing neo‐vessel formation. Genetically modified stem cells are also being applied for promoting angiogenesis regarding their ability to considerably overexpress and secrete angiogenic bioactive molecules. Yet, conducting further research seems necessary to precisely identify molecular mechanisms behind the proangiogenic potential of stem cells, including the signaling pathways and regulatory molecules such as microRNAs. In conclusion, stem cells' pivotal roles in promoting angiogenesis and consequent improved cardiac healing and remodeling processes should not be ignored, especially in the case of stem cell‐derived extracellular vesicles.Keywords
This publication has 145 references indexed in Scilit:
- Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cellsProceedings of the National Academy of Sciences of the United States of America, 2013
- Proangiogenic features of Wharton's jelly-derived mesenchymal stromal/stem cells and their ability to form functional vesselsThe International Journal of Biochemistry & Cell Biology, 2013
- Factors Secreted by Mesenchymal Stem Cells and Endothelial Progenitor Cells Have Complementary Effects on Angiogenesis In VitroStem Cells and Development, 2013
- Spindle Shaped Human Mesenchymal Stem/Stromal Cells from Amniotic Fluid Promote NeovascularizationPLOS ONE, 2013
- Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct ReprogrammingCell Stem Cell, 2012
- Endothelial Progenitor Cells Induce a Phenotype Shift in Differentiated Endothelial Cells towards PDGF/PDGFRβ Axis-Mediated AngiogenesisPLOS ONE, 2010
- IFATS Collection: Human Adipose Tissue-Derived Stem Cells Induce Angiogenesis and Nerve Sprouting Following Myocardial Infarction, in Conjunction with Potent Preservation of Cardiac FunctionThe International Journal of Cell Cloning, 2009
- Endothelial progenitor cells in neovascularization of infarcted myocardiumJournal of Molecular and Cellular Cardiology, 2008
- Engineering Robust and Functional Vascular Networks In Vivo With Human Adult and Cord Blood–Derived Progenitor CellsCirculation Research, 2008
- The Bone Marrow—Cardiac Axis of Myocardial RegenerationProgress in Cardiovascular Diseases, 2007