Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA
Open Access
- 4 May 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cell Death Discovery
- Vol. 6 (1), 1-15
- https://doi.org/10.1038/s41420-020-0268-1
Abstract
IK depletion leads to an aberrant mitotic entry because of chromosomal misalignment through the enhancement of Aurora B activity at the interphase. Here, we demonstrate that IK, a spliceosomal component, plays a crucial role in the proper splicing of the ATM pre-mRNA among other genes related with the DNA Damage Response (DDR). Intron 1 in the ATM pre-mRNA, having lengths ATM pre-mRNA and USP47 contributes toward the stabilization of IK.Keywords
Funding Information
- National Research Foundation of Korea (2016R1A5A1011974)
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