Spectroscopic Study of the Molecular Structure of the New Hybrid with a Potential Two-Way Antibacterial Effect
Open Access
- 7 March 2021
- Vol. 26 (5), 1442
- https://doi.org/10.3390/molecules26051442
Abstract
Bacterial strains become resistant to almost all classes of antibiotics, which makes it necessary to look for new substitutes. The non-absorbable ciprofloxacin–biguanide bismuth complex, used locally, may be a good alternative to a conventional therapy. The purpose of this study was to study the structure of the proposed ciprofloxacin (CIP) -bismuth(III)—chlorhexidine (CHX) composite (CIP-Bi-CHX). The spectroscopic techniques such as UV-VIS (ultraviolet-visible) spectroscopy, FTIR (Fourier-transform infrared) spectroscopy and NMR (Nuclear Magnetic Resonance) spectroscopy were used for structure characterization of the hybrid compound. The performed analysis confirmed the presence of the two active components—CIP and CHX and revealed the possible coordination sites of the ligands with bismuth ion in the metallo-organic structure. Spectroscopic study showed that the complexation between Bi(III) and CIP occurs through the carboxylate and ketone groups of the quinolone ring, while CHX combines with the central ion via the biguanide moieties.Keywords
This publication has 44 references indexed in Scilit:
- Metal Complexes of Quinolone Antibiotics and Their Applications: An UpdateMolecules, 2013
- Spectroscopy and Speciation Studies on the Interactions of Aluminum (III) with Ciprofloxacin and β-Nicotinamide Adenine Dinucleotide Phosphate in Aqueous SolutionsMolecules, 2012
- Perspective: the potential of pyrazole-based compounds in medicineBioMetals, 2011
- Multinuclear solid state NMR investigation of two polymorphic forms of Ciprofloxacin-saccharinatePhysical Chemistry Chemical Physics, 2011
- Dual-acting hybrid antibiotics: a promising strategy to combat bacterial resistanceExpert Opinion on Drug Discovery, 2010
- Synthesis and characterization of new copper(II) complex compounds with chlorhexidine. Part IOpen Chemistry, 2010
- Effects of substituents on the NMR features of basic bicyclic ring systems of fluoroquinolone antibiotics and the relationships between NMR chemical shifts, molecular descriptors and drug-likeness parametersActa Pharmaceutica, 2010
- Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pyloriActa Pharmaceutica, 2009
- 1H, 13C and 15N NMR spectra of ciprofloxacinMagnetic Resonance in Chemistry, 2004
- Novel oxazolidinone–quinolone hybrid antimicrobialsBioorganic & Medicinal Chemistry Letters, 2003