Superior Long‐Term Outcomes of Adult Living Donor Liver Transplantation: A Cumulative Single‐Center Cohort Study With 20 Years of Follow‐Up
- 6 December 2021
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Liver Transplantation
- Vol. 28 (5), 834-842
- https://doi.org/10.1002/lt.26386
Abstract
Living donor liver transplantation (LDLT) is an attractive alternative to deceased donor liver transplantation (DDLT). Although both modalities have similar short-term outcomes, long-term outcomes are not well studied. Herein, we compared 20-year outcomes of 668 adults who received LDLT with1596 DDLT at the largest liver transplant (LT) program in Canada. Recipients of LDLT were significantly younger and more often male than DDLT (pP = 0.02), as were graft survival rates LDLT (91%, 67%, and 50%) versus (90%, 65%, and 44.3%, respectively, for DDLT; log-rank P = 0.31). After multivariable adjustment, LDLT and DDLT were associated with a similar hazard of patient and graft survival. Our data of 20-years follow-up of LDLT from a single, large Western center demonstrates excellent long-term outcomes for recipients of LDLT.Keywords
This publication has 20 references indexed in Scilit:
- Living donor versus deceased donor liver transplantation: a surgeon-matched comparison of recipient morbidity and outcomesTransplant International, 2013
- Endoscopic Management of Biliary Complications After Adult Living-Donor Versus Deceased-Donor Liver TransplantationTransplantation, 2009
- Resource Utilization of Living Donor Versus Deceased Donor Liver Transplantation Is Similar at an Experienced Transplant CenterAmerican Journal of Transplantation, 2009
- Recipient Morbidity After Living and Deceased Donor Liver Transplantation: Findings from the A2ALL Retrospective Cohort StudyAmerican Journal of Transplantation, 2008
- Biliary Strictures in 130 Consecutive Right Lobe Living Donor Liver Transplant Recipients: Results of a Western CenterAmerican Journal of Transplantation, 2006
- Operative Outcomes of Adult-to-Adult Right Lobe Live Donor Liver TransplantationAnnals of Surgery, 2006
- Small‐for‐Size Syndrome After Partial Liver Transplantation: Definition, Mechanisms of Disease and Clinical ImplicationsAmerican Journal of Transplantation, 2005
- Analysis and Outcomes of Right Lobe Hepatectomy in 101 Consecutive Living DonorsAmerican Journal of Transplantation, 2005
- Hepatitis C recurrence is more severe after living donor compared to cadaveric liver transplantationJournal of Hepatology, 2004
- Liver Transplantation for Hepatocellular CarcinomaAnnals of Surgery, 2001