Emerging landscape of circular RNAs as biomarkers and pivotal regulators in osteosarcoma
- 26 May 2020
- journal article
- review article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 235 (12), 9037-9058
- https://doi.org/10.1002/jcp.29754
Abstract
Osteosarcoma represents the most prevailing primary bone tumor and the third most common cancer in children and adolescents worldwide. Among noncoding RNAs, circular RNAs (circRNAs) refer to a unique class in the shape of a covalently closed continuous loop with neither 5′ caps nor 3′‐polyadenylated tails, which are generated through back‐splicing. Recently, with the development of whole‐genome and transcriptome sequencing technologies, a growing number of circRNAs have been found aberrantly expressed in multiple diseases, including osteosarcoma. circRNA are capable of various biological functions including miRNA sponge, mediating alternatives, regulating genes at posttranscriptional levels, and interacting with proteins, indicating a pivotal role of circRNA in cancer initiation, progression, chemoresistance, and immune response. Moreover, circRNAs have been thrust into the spotlight as potential biomarkers and therapeutic targets in osteosarcoma. Herein, we briefly summarize the origin and biogenesis of circRNA with current knowledge of circRNA in tumorigenesis of osteosarcoma, aiming to elucidate the specific role and clinical implication of circRNAs in osteosarcoma.Keywords
Funding Information
- National Natural Science Foundation of China (81902745)
- China Scholarship Council (201806375067, 201806375068)
This publication has 157 references indexed in Scilit:
- circRNA Biogenesis Competes with Pre-mRNA SplicingMolecular Cell, 2014
- Detecting and characterizing circular RNAsNature Biotechnology, 2014
- Circular Intronic Long Noncoding RNAsMolecular Cell, 2013
- Cell-Type Specific Features of Circular RNA ExpressionPLoS Genetics, 2013
- Circular RNAs are abundant, conserved, and associated with ALU repeatsRNA, 2012
- An integrated encyclopedia of DNA elements in the human genomeNature, 2012
- Gene silencing by microRNAs: contributions of translational repression and mRNA decayNature Reviews Genetics, 2011
- Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcriptionNature, 2008
- Circular transcripts of the testis-determining gene Sry in adult mouse testisCell, 1993
- Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures.Proceedings of the National Academy of Sciences of the United States of America, 1976