The hidden burden of influenza: A review of the extra‐pulmonary complications of influenza infection
Top Cited Papers
Open Access
- 13 September 2017
- journal article
- review article
- Published by Wiley in Influenza and Other Respiratory Viruses
- Vol. 11 (5), 372-393
- https://doi.org/10.1111/irv.12470
Abstract
Severe influenza infection represents a leading cause of global morbidity and mortality. Although influenza is primarily considered a viral infection that results in pathology limited to the respiratory system, clinical reports suggest that influenza infection is frequently associated with a number of clinical syndromes that involve organ systems outside the respiratory tract. A comprehensive MEDLINE literature review of articles pertaining to extra-pulmonary complications of influenza infection, using organ-specific search terms, yielded 218 articles including case reports, epidemiologic investigations, and autopsy studies that were reviewed to determine the clinical involvement of other organs. The most frequently described clinical entities were viral myocarditis and viral encephalitis. Recognition of these extra-pulmonary complications is critical to determining the true burden of influenza infection and initiating organ-specific supportive care.Keywords
Funding Information
- Infectious Diseases Society of America
- National Institute on Aging (R03AG045088)
- National Institutes of Health (KLS2TR001109)
- National Institute of Allergy and Infectious Diseases (NIH1K23AI121516)
- Bill and Melinda Gates Foundation
This publication has 209 references indexed in Scilit:
- Productive Infection of Human Skeletal Muscle Cells by Pandemic and Seasonal Influenza A(H1N1) VirusesPLOS ONE, 2013
- Cytokine responses in patients with mild or severe influenza A(H1N1)pdm09Journal of Clinical Virology, 2013
- Myopericarditis and exertional rhabdomyolysis following an influenza A (H3N2) infectionBMC Infectious Diseases, 2013
- Acute kidney injury among critically ill patients with pandemic H1N1 influenza A in Canada: cohort studyBMC Nephrology, 2013
- Influenza Infection and Risk of Acute Myocardial Infarction in England and Wales: A CALIBER Self-Controlled Case Series StudyThe Journal of Infectious Diseases, 2012
- Oseltamivir Inhibits H7 Influenza Virus Replication in Mice Inoculated by the Ocular RouteAntimicrobial Agents and Chemotherapy, 2012
- Circulating Influenza Virus, Climatic Factors, and Acute Myocardial Infarction: A Time Series Study in England and Wales and Hong KongThe Journal of Infectious Diseases, 2011
- Bleeding Follicular Conjunctivitis due to Influenza H1N1 VirusJournal of Ophthalmology, 2010
- Pneumonia and Respiratory Failure from Swine-Origin Influenza A (H1N1) in MexicoThe New England Journal of Medicine, 2009
- Infection-Triggered Familial or Recurrent Cases of Acute Necrotizing Encephalopathy Caused by Mutations in a Component of the Nuclear Pore, RANBP2American Journal of Human Genetics, 2009