Lower Cord Blood IL-17 and IL-25, but Not Other Epithelial Cell-Derived Cytokines Are Associated with Atopic Dermatitis in Infancy
- 7 January 2021
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 182 (6), 474-478
- https://doi.org/10.1159/000512919
Abstract
Background: There is a growing need for early biomarkers that may predict the development of atopic dermatitis (AD). As alterations in skin barrier may be a primary event in disease pathogenesis, epithelial cell (EC) cytokines expression patterns may be a potential biomarker in early life to target allergy preventive strategies towards “at-risk” infants. Objectives: The aim of this longitudinal investigation was to examine from birth over the course of infancy levels of the EC cytokines: thymic stromal lymphopoietin (TSLP), interleukin (IL)-33, IL-25, and IL-17 in infants at high-risk of AD due to maternal atopy. Method: We collected (n = 31) cord blood samples from atopic mothers and followed up their infants at 4–6 and 12 months of age for collection of peripheral venous blood samples and diagnosis of AD. TSLP concentration was measured by ELISA after acetone precipitation of the samples. IL-33, IL-25, and IL-17 levels were measured by Luminex. Results: Seven infants who developed AD had lower levels of IL-25 and IL-17 at birth compared to the 24 infants who did not develop AD by 12 months of age. Conclusions: Lower cord blood levels of IL-17 and IL-25, but not other EC cytokines, were associated with the onset of AD during infancy. Our results highlight that the in-utero period appears critical, and potential maternal influences on cord blood EC-derived cytokine concentrations requires further exploration.Keywords
This publication has 9 references indexed in Scilit:
- Divergent Effects of Acute and Prolonged Interleukin 33 Exposure on Mast Cell IgE-Mediated FunctionsFrontiers in Immunology, 2019
- TSLP, IL‐31, IL‐33 and sST2 are new biomarkers in endophenotypic profiling of adult and childhood atopic dermatitisJournal of the European Academy of Dermatology and Venereology, 2016
- Predictors of interleukin‐33 and thymic stromal lymphopoietin levels in cord bloodPediatric Allergy and Immunology, 2015
- Which infants with eczema are at risk of food allergy? Results from a population‐based cohortClinical & Experimental Allergy, 2014
- The Atopic March: Progression from Atopic Dermatitis to Allergic Rhinitis and AsthmaAlternative & Integrative Medicine, 2014
- IL-33 Induces a Hyporesponsive Phenotype in Human and Mouse Mast CellsThe Journal of Immunology, 2013
- Decrease in circulating Th17 cells correlates with increased levels of CCL17, IgE and eosinophils in atopic dermatitisJournal of Dermatological Science, 2011
- Increased serum thymic stromal lymphopoietin in children with atopic dermatitisPediatric Allergy and Immunology, 2010
- Possible Pathogenic Role of Th17 Cells for Atopic DermatitisJournal of Investigative Dermatology, 2008