Design of Polymeric Carriers for Intracellular Peptide Delivery in Oncology Applications
- 10 February 2021
- journal article
- review article
- Published by American Chemical Society (ACS) in Chemical Reviews
- Vol. 121 (18), 11653-11698
- https://doi.org/10.1021/acs.chemrev.0c00963
Abstract
In recent decades, peptides, which can possess high potency, excellent selectivity, and low toxicity, have emerged as promising therapeutics for cancer applications. Combined with an improved understanding of tumor biology and immuno-oncology, peptides have demonstrated robust antitumor efficacy in preclinical tumor models. However, the translation of peptides with intracellular targets into clinical therapies has been severely hindered by limitations in their intrinsic structure, such as low systemic stability, rapid clearance, and poor membrane permeability, that impede intracellular delivery. In this Review, we summarize recent advances in polymer-mediated intracellular delivery of peptides for cancer therapy, including both therapeutic peptides and peptide antigens. We highlight strategies to engineer polymeric materials to increase peptide delivery efficiency, especially cytosolic delivery, which plays a crucial role in potentiating peptide-based therapies. Finally, we discuss future opportunities for peptides in cancer treatment, with an emphasis on the design of polymer nanocarriers for optimized peptide delivery.Keywords
Funding Information
- U.S. Department of Health and Human Services (1R01CA177272, 1R21CA232430)
- U.S. Department of Health and Human Services (2R01NS064404)
- National Science Foundation (DGE-1762114)
- U.S. Department of Defense (W81XWH-20-1-0782)
This publication has 280 references indexed in Scilit:
- Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survivalProceedings of the National Academy of Sciences of the United States of America, 2013
- Engineering of blended nanoparticle platform for delivery of mitochondria-acting therapeuticsProceedings of the National Academy of Sciences of the United States of America, 2012
- A stapled BIM peptide overcomes apoptotic resistance in hematologic cancersJCI Insight, 2012
- Anticancer β-Hairpin Peptides: Membrane-Induced Folding Triggers ActivityJournal of the American Chemical Society, 2012
- Design of polymeric nanoparticles for biomedical delivery applicationsChemical Society Reviews, 2012
- A HA2-Fusion tag limits the endosomal release of its protein cargo despite causing endosomal lysisBiochimica et Biophysica Acta (BBA) - General Subjects, 2011
- Biomedical applications of biodegradable polymersJournal of Polymer Science Part B: Polymer Physics, 2011
- Development of JNK2-Selective Peptide Inhibitors That Inhibit Breast Cancer Cell MigrationACS Chemical Biology, 2011
- The utilization of pathogen-like cellular trafficking by single chain block copolymerBiomaterials, 2010
- Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic DiseaseCell, 2010