Aluminum Nanoparticles Acting as a Pulmonary Vaccine Adjuvant-Delivery System (VADS) Able to Safely Elicit Robust Systemic and Mucosal Immunity
- 9 May 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Inorganic and Organometallic Polymers and Materials
- Vol. 30 (10), 4203-4217
- https://doi.org/10.1007/s10904-020-01572-z
Abstract
Vulnerability of respiratory mucosa to invasions of airborne pathogens, such as SARS-CoV, MERS-CoV and avian viruses which sometimes cause a life-threatening epidemic and even pandemic, underscores significance of developing a pulmonary vaccine adjuvant-delivery system (VADS). Herein, 30-nm aluminum nanoparticles (ANs), unlike the mostly used adjuvant alum which is unsuitable for delivering pulmonary vaccines due to side effects, proved able to act as a VADS fitting inhalation immunization to elicit wide-spread anti-antigen immunity. In vitro ANs facilitated cellular uptake of their cargos and, after pulmonary vaccination, induced mouse production of high levels of anti-antigen IgG in serum and IgA in saliva, nasal, bronchoalveolar and also vaginal fluids. Besides, IFN-γ and anti-antigen IgG2a enriched in immunized mice which meanwhile showed no obvious lung inflammation indicated balanced Th1/Th2 responses were safely induced. These outcomes suggest ANs may be an efficient pulmonary VADS for defending against pathogens, especially, the ones invading hosts via respiratory system. Graphic Abstract Aluminum nanoparticles can safely induce humoral and cellular immunity at systemic and mucosal level through pulmonary vaccination to contrast the conventional adjuvant alum.Keywords
Funding Information
- National Natural Science Foundation of China (81703449)
- Anhui Provincial Natural Science Foundation (1708085QH196)
- Human Resource & Social Security Department of Anhui Province (2018H173)
This publication has 57 references indexed in Scilit:
- Modern Subunit Vaccines: Development, Components, and Research OpportunitiesChemMedChem, 2013
- “IDEAL” vaccines for resource poor settingsVaccine, 2011
- Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour responseNature Nanotechnology, 2011
- Vaccine delivery: a matter of size, geometry, kinetics and molecular patternsNature Reviews Immunology, 2010
- The immunobiology of aluminium adjuvants: how do they really work?Trends in Immunology, 2010
- Alveolar Surfactant Homeostasis and the Pathogenesis of Pulmonary DiseaseAnnual Review of Medicine, 2010
- Mucosal vaccines: the promise and the challengeNature Reviews Immunology, 2006
- An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrowJournal of Immunological Methods, 1999
- The Role of CD40 Ligand in Costimulation and T‐Cell ActivationImmunological Reviews, 1996
- Immunological notes. XVII–XXIVThe Journal of Pathology and Bacteriology, 1926