Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy
Open Access
- 6 April 2020
- journal article
- research article
- Published by Wiley in Advanced Science
- Vol. 7 (10), 1903585
- https://doi.org/10.1002/advs.201903585
Abstract
Excess electrons play important roles for the construction of superficial active sites on nanocatalysts. However, providing excess electrons to nanocatalysts in vivo is still a challenge, which limits the applications of nanocatalysts in biomedicine. Herein, auger electrons (AEs) emitted from radionuclide 125 (125I) are used in situ to construct active sites in a nanocatalyst (TiO2) and the application of this method is further extended to cancer catalytic internal radiotherapy (CIRT). The obtained 125I‐TiO2 nanoparticles first construct superficial Ti3+ active sites via the reaction between Ti4+ and AEs. Then Ti3+ stretches and weakens the OH bond of the absorbed H2O, thus enhancing the radiolysis of H2O molecules and generating hydroxyl radicals (•OH). All in vitro and in vivo results demonstrate a good CIRT performance. These findings will broaden the application of radionuclides and introduce new perspectives to nanomedicine.Funding Information
- National Natural Science Foundation of China (81471714, 81871390, 51872094)
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