Anti-Aminoacyl Transfer-RNA-Synthetases (Anti-tRNA) Autoantibodies Associated with Interstitial Lung Disease: Pulmonary Disease Progression has a Persistent Elevation of the Th17 Cytokine Profile
Open Access
- 5 May 2020
- journal article
- research article
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 9 (5), 1356
- https://doi.org/10.3390/jcm9051356
Abstract
Anti-tRNA autoantibodies are associated with interstitial lung disease (ILD), in at least two clinical scenarios: the anti-synthetase syndrome (ASSD) and interstitial pneumonia with autoimmune features (IPAF). Under pathological conditions, cytokines indicate the participating elements and the course of inflammatory phenomena. We aimed to quantify serum concentrations of different inflammatory cytokines profiles in patients with anti-tRNA associated ILD (anti-tRNA-ILD) and estimate the association between these and ILD improvement and progression. Serum levels of 18 cytokines from baseline and after six months of treatment of ILD patients’ positives to anti-tRNA were included in the current study. At six months, patients were classified as with or without ILD progression. A total of 39 patients were included (10 anti-Jo1, eight anti-PL7, 11 anti-PL12, and 10 anti-Ej). Three patients (7.6%) had ILD progression (progressors patients, PP) and showed statistically higher levels in IL-4, IL-10, IL-17A, IL-22, GM-CSF, IL-1β, IL-6, IL-12, IL-18, and TNF-α, compared to patients without disease progression (no progressors patients, NPP). IL-17A, IL-1β, and IL-6 (T-helper-lymphocyte (Th)17 inflammatory cytokine profile) were elevated and had a high discriminatory capacity in distinguishing ILD PP of those NPP at follow-up. Overall, there is an association between the cytokines of the Th17 inflammatory profile and the ASSD progression.This publication has 40 references indexed in Scilit:
- Animal Models of Inflammatory MyopathyCurrent Rheumatology Reports, 2012
- The lung as a possible target for the immune reaction in myositisArthritis Research & Therapy, 2011
- Diagnostic performance and validation of autoantibody testing in myositis by a commercial line blot assayRheumatology, 2010
- Interleukin-17 and Type 17 Helper T CellsThe New England Journal of Medicine, 2009
- Interstitial Lung Disease in Systemic SclerosisAmerican Journal of Respiratory and Critical Care Medicine, 2008
- A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullinationArthritis & Rheumatism, 2005
- Standardisation of spirometryEuropean Respiratory Journal, 2005
- General considerations for lung function testingEuropean Respiratory Journal, 2005
- Myositis autoantibody inhibits histidyl-tRNA synthetase: a model for autoimmunityNature, 1983
- Polymyositis and DermatomyositisThe New England Journal of Medicine, 1975