Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain
Open Access
- 4 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 11 (1), 1-8
- https://doi.org/10.1038/s41598-021-82548-y
Abstract
The aim of this study was to estimate the incidence of diabetes mellitus in the Basque Country and the risk factors involved in the disease by reassessing an adult population after 7 years of follow-up. In the previous prevalence study, 847 people older than 18 years were randomly selected from all over the Basque Country and were invited to answer a medical questionnaire, followed by a physical examination and an oral glucose tolerance test. In the reassessment, the same variables were collected and the resulting cohort comprised 517 individuals of whom 43 had diabetes at baseline. The cumulative incidence of diabetes was 4.64% in 7 years and the raw incidence rate was 6.56 cases/1000 person-years (95%CI: 4.11-9.93). Among the incident cases, 59% were undiagnosed. The most strongly associated markers by univariate analyses were age >60 years, dyslipidaemia, prediabetes and insulin resistance. We also found association with hypertension, obesity, family history of diabetes and low education level. Multivariate analysis adjusted for age and sex showed that a set of risk factors assessed together (dyslipidaemia, waist-to-hip-ratio and family history of diabetes) had great predictive value (AUC-ROC=0.899, 95%CI: 0.846-0.953, p=0.942), which suggests the need for early intervention before the onset of prediabetes.This publication has 28 references indexed in Scilit:
- Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studiesThe Lancet, 2010
- Incidence of type 2 diabetes in southern Spain (Pizarra Study)European Journal of Clinical Investigation, 2008
- Evolución de la prevalencia de la diabetes tipo 2 en población adulta españolaMedicina Clinica, 2007
- Population-Based Incidence of Type 2 Diabetes in Northern SpainDiabetes Care, 2007
- Metabolic syndrome—a new world‐wide definition. A Consensus Statement from the International Diabetes FederationDiabetic Medicine, 2006
- Population-Based Incidence Rates and Risk Factors for Type 2 Diabetes in White IndividualsDiabetes, 2004
- Incidence, prevalence and coronary heart disease risk level in known Type 2 diabetes: a sentinel practice network study in the Basque Country, SpainDiabetologia, 2003
- Long-term changes in insulin action and insulin secretion associated with gain, loss, regain and maintenance of body weightDiabetologia, 2000
- Estudio prospectivo a 10 años sobre la incidencia y factores de riesgo de diabetes mellitus tipo 2Medicina Clinica, 2000
- Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in manDiabetologia, 1985