No abnormal hexanucleotide repeat expansion of C9ORF72 in Japanese schizophrenia patients
- 13 August 2014
- journal article
- Published by Springer Science and Business Media LLC in Journal of Neural Transmission
- Vol. 122 (5), 731-732
- https://doi.org/10.1007/s00702-014-1295-y
Abstract
Abnormal hexanucleotide repeat expansion of C9ORF72 is known to cause neurodegenerative disorders such as frontotemporal dementia. Additionally, patients with psychotic symptoms are more likely to have abnormal hexanucleotide repeat expansion than are patients without them. We investigated the hexanucleotide repeat sizes of C9ORF72 in 466 Japanese schizophrenia patients. We found no abnormal hexanucleotide repeat expansion. In conclusion, C9ORF72 may not be responsible for schizophrenia susceptibility in the Japanese population.Keywords
This publication has 12 references indexed in Scilit:
- The C9ORF72 hexanucleotide repeat expansion is a rare cause of schizophreniaNeurobiology of Aging, 2014
- Searching for Grendel: origin and global spread of the C9ORF72 repeat expansion.Acta Neuropathologica, 2014
- C9ORF72 hexanucleotide repeat expansion as a rare cause of bipolar disorderBipolar Disorders, 2013
- C9ORF72 repeat expansions not detected in a group of patients with schizophreniaNeurobiology of Aging, 2013
- C9ORF72 expansion in a family with bipolar disorderBipolar Disorders, 2013
- Large C9orf72 Hexanucleotide Repeat Expansions Are Seen in Multiple Neurodegenerative Syndromes and Are More Frequent Than Expected in the UK PopulationAmerican Journal of Human Genetics, 2013
- Analysis of C9orf72 repeat expansion in 563 Japanese patients with amyotrophic lateral sclerosisNeurobiology of Aging, 2012
- Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALSNeuron, 2011
- A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTDNeuron, 2011
- ABNORMALITIES OF CEREBRAL BLOOD FLOW DISTRIBUTION IN PATIENTS WITH CHRONIC SCHIZOPHRENIAActa Psychiatrica Scandinavica, 1974