Comorbidity Pattern Analysis for Predicting Amyotrophic Lateral Sclerosis
Open Access
- 31 January 2021
- journal article
- research article
- Published by MDPI AG in Applied Sciences
- Vol. 11 (3), 1289
- https://doi.org/10.3390/app11031289
Abstract
Electronic Medical Records (EMRs) can be used to create alerts for clinicians to identify patients at risk and to provide useful information for clinical decision-making support. In this study, we proposed a novel approach for predicting Amyotrophic Lateral Sclerosis (ALS) based on comorbidities and associated indicators using EMRs. The medical histories of ALS patients were analyzed and compared with those of subjects without ALS, and the associated comorbidities were selected as features for constructing the machine learning and prediction model. We proposed a novel weighted Jaccard index (WJI) that incorporates four different machine learning techniques to construct prediction systems. Alternative prediction models were constructed based on two different levels of comorbidity: single disease codes and clustered disease codes. With an accuracy of 83.7%, sensitivity of 78.8%, specificity of 85.7%, and area under the receiver operating characteristic curve (AUC) value of 0.907 for the single disease code level, the proposed WJI outperformed the traditional Jaccard index (JI) and scoring methods. Incorporating the proposed WJI into EMRs enabled the construction of a prediction system for analyzing the risk of suffering a specific disease based on comorbidity combinatorial patterns, which could provide a fast, low-cost, and noninvasive evaluation approach for early diagnosis of a specific disease.Funding Information
- National Taipei University of Technology (NTUT-IJRP-109-08)
This publication has 25 references indexed in Scilit:
- Patterns of Multimorbidity in the Aged Population. Results from the KORA-Age StudyPLOS ONE, 2012
- Amyotrophic lateral sclerosisThe Lancet, 2011
- Propensity score estimation: neural networks, support vector machines, decision trees (CART), and meta-classifiers as alternatives to logistic regressionJournal of Clinical Epidemiology, 2010
- Amyotrophic lateral sclerosisOrphanet Journal of Rare Diseases, 2009
- Can Electronic Medical Record Systems Transform Health Care? Potential Health Benefits, Savings, And CostsHealth Affairs, 2005
- A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary intervention: Development and initial validationJournal of the American College of Cardiology, 2004
- A simple risk score for prediction of contrast-induced nephropathy after percutaneous coronary interventionDevelopment and initial validationJournal of the American College of Cardiology, 2004
- The International Prostate Symptom Score in a community‐based sample of men between 55 and 74 years of age: prevalence and correlation of symptoms with age, prostate volume, flow rate and residual urine volumeBJU International, 1995
- Detection of Postnatal DepressionThe British Journal of Psychiatry, 1987
- A General Coefficient of Similarity and Some of Its PropertiesBiometrics, 1971