The protective effects of escitalopram on synaptic plasticity in the CA1 region of chronically stressed and non‐stressed male rats
- 22 August 2022
- journal article
- research article
- Published by Wiley in International Journal of Developmental Neuroscience
- Vol. 82 (8), 747-757
- https://doi.org/10.1002/jdn.10224
Abstract
Introduction: Stress impairs cognitive processes and escitalopram affects them in various ways. The present study has compared the protective effects of two escitalopram doses on neural excitability and synaptic plasticity in the CA1 region of chronically stressed and non-stressed male rats. Methods: Forty-nine rats were randomly allocated into seven groups: Control (Co), stress (St), sham (Sh), escitalopram 10 and 20 mg/kg (Esc10 and Esc20), and stress-escitalopram 10 and 20 mg/kg (St-Esc10 and St-Esc20). Induction of restraint stress (6 h/day) and escitalopram injections were performed for 14 days. The fEPSP slope and amplitude were measured according to input-output functions and after the LTP induction in the hippocampal CA1 region. Also, serum corticosterone levels were evaluated in all experimental groups. Results: The fEPSP slope and amplitude decreased significantly in the St group and increased significantly in the Esc10 group compared with the Co group. In non-stressed states, significant increases in slope and amplitude occurred in the Esc10 group compared with the Esc20 group. Notably, these values were also significantly enhanced by both escitalopram doses under stressed conditions. Moreover, serum corticosterone levels significantly elevated in the St group although its levels decreased in both St-Esc groups compared with the St. Conclusion: Stress significantly attenuated neural excitability and long-term plasticity in the CA1 area. Only escitalopram 10 mg/kg improved synaptic excitability, as well as LTP induction and maintenance in non-stressed subjects even more than normal levels. However, under stress conditions, both escitalopram doses enhanced neural excitability and memory probably due to reduced serum corticosterone levels.Keywords
Funding Information
- Isfahan University of Medical Sciences
This publication has 57 references indexed in Scilit:
- Learning and Memory Alterations Are Associated with Hippocampal N-acetylaspartate in a Rat Model of Depression as Measured by 1H-MRSPLOS ONE, 2011
- Escitalopram reduces circulating pro-inflammatory cytokines and improves depressive behavior without affecting sleep in a rat model of post-cardiac infarct depressionBehavioural Brain Research, 2011
- Differential expression of molecular markers of synaptic plasticity in the hippocampus, prefrontal cortex, and amygdala in response to spatial learning, predator exposure, and stress-induced amnesiaHippocampus, 2011
- Effects of S‐citalopram, citalopram, and R‐citalopram on the firing patterns of dopamine neurons in the ventral tegmental area, N‐methyl‐D‐aspartate receptor‐mediated transmission in the medial prefrontal cortex and cognitive function in the ratSynapse, 2010
- Antidepressants are a rational complementary therapy for the treatment of Alzheimer's diseaseMolecular Neurodegeneration, 2010
- Remodelling by early-life stress of NMDA receptor-dependent synaptic plasticity in a gene–environment rat model of depressionInternational Journal of Neuropsychopharmacology, 2008
- LTP after Stress: Up or Down?Neural Plasticity, 2007
- Pharmacokinetic/Pharmacodynamic Feedback Modelling of the Functional Corticosterone Response in Rats after Acute Treatment with EscitalopramBasic & Clinical Pharmacology & Toxicology, 2007
- Behavioral and electrophysiological studies of chronic oral administration of L-type calcium channel blocker verapamil on learning and memory in ratsBehavioural Brain Research, 2006
- How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative ActionsEndocrine Reviews, 2000