A Historic Perspective and Overview of H-Ras Structure, Oncogenicity, and Targeting
- 1 April 2020
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Molecular Cancer Therapeutics
- Vol. 19 (4), 999-1007
- https://doi.org/10.1158/1535-7163.mct-19-0660
Abstract
H-Ras is a unique isoform of the Ras GTPase family, one of the most prominently mutated oncogene families across the cancer landscape. Relative to other isoforms, though, mutations of H-Ras account for the smallest proportion of mutant Ras cancers. Yet, in recent years, there have been renewed efforts to study this isoform, especially as certain H-Ras–driven cancers, like those of the head and neck, have become more prominent. Important advances have therefore been made not only in the understanding of H-Ras structural biology but also in approaches designed to inhibit and impair its signaling activity. In this review, we outline historic and present initiatives to elucidate the mechanisms of H-Ras–dependent tumorigenesis as well as highlight ongoing developments in the quest to target this critical oncogene.This publication has 81 references indexed in Scilit:
- The small GTPase HRas shapes local PI3K signals through positive feedback and regulates persistent membrane extension in migrating fibroblastsMolecular Biology of the Cell, 2013
- The evolving concept of cancer and metastasis stem cellsThe Journal of cell biology, 2012
- Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancerNature, 2012
- A Comprehensive Survey of Ras Mutations in CancerCancer Research, 2012
- Regulating the regulator: post-translational modification of RASNature Reviews Molecular Cell Biology, 2011
- Analysis of Binding Site Hot Spots on the Surface of Ras GTPaseJournal of Molecular Biology, 2011
- Rabex-5 Ubiquitin Ligase Activity Restricts Ras Signaling to Establish Pathway Homeostasis in DrosophilaCurrent Biology, 2010
- Feedback Regulation of Ras Signaling by Rabex-5-Mediated UbiquitinationCurrent Biology, 2010
- Small-Molecule Inhibitors of the Rce1p CaaX ProteaseSLAS Discovery, 2007
- GEFs and GAPs: Critical Elements in the Control of Small G ProteinsCell, 2007