Global patterns in genomic diversity underpinning the evolution of insecticide resistance in the aphid crop pest Myzus persicae
Open Access
- 7 July 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Communications Biology
- Vol. 4 (1), 1-16
- https://doi.org/10.1038/s42003-021-02373-x
Abstract
The aphid Myzus persicae is a destructive agricultural pest that displays an exceptional ability to develop resistance to both natural and synthetic insecticides. To investigate the evolution of resistance in this species we generated a chromosome-scale genome assembly and living panel of >110 fully sequenced globally sampled clonal lines. Our analyses reveal a remarkable diversity of resistance mutations segregating in global populations of M. persicae. We show that the emergence and spread of these mechanisms is influenced by host–plant associations, uncovering the widespread co‐option of a host-plant adaptation that also offers resistance against synthetic insecticides. We identify both the repeated evolution of independent resistance mutations at the same locus, and multiple instances of the evolution of novel resistance mechanisms against key insecticides. Our findings provide fundamental insights into the genomic responses of global insect populations to strong selective forces, and hold practical relevance for the control of pests and parasites.Keywords
This publication has 104 references indexed in Scilit:
- The Drosophila melanogaster Genetic Reference PanelNature, 2012
- A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing dataBioinformatics, 2011
- Eukaryotic Gene Prediction Using GeneMark.hmm‐E and GeneMark‐ESCurrent Protocols in Bioinformatics, 2011
- The variant call format and VCFtoolsBioinformatics, 2011
- The Sequence Alignment/Map format and SAMtoolsBioinformatics, 2009
- A continuum of genetic divergence from sympatric host races to species in the pea aphid complexProceedings of the National Academy of Sciences of the United States of America, 2009
- PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage AnalysesAmerican Journal of Human Genetics, 2007
- Application of Phylogenetic Networks in Evolutionary StudiesMolecular Biology and Evolution, 2005
- Haploview: analysis and visualization of LD and haplotype mapsBioinformatics, 2004
- The Relative Rates of Evolution of Sex Chromosomes and AutosomesThe American Naturalist, 1987