Association between prenatal phthalate exposure and gestational metabolic syndrome parameters: a systematic review of epidemiological studies
- 5 March 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Environmental Science and Pollution Research
- Vol. 28 (17), 20921-20938
- https://doi.org/10.1007/s11356-021-13120-4
Abstract
The relationship of intrauterine phthalate exposure with gestational metabolic syndrome (GMS) parameters is inconsistently reported. We performed a systematic review to evaluate the association between prenatal phthalate exposure and GMS parameters. A literature search was performed in three databases. According to the defined PECOS statement, eligible studies were identified. The method and result for each study was qualitatively summarized with great emphasis on study design and exposure assessment. Fourteen studies were included in the present systematic review. Two studies used one-spot serum sample for evaluation of phthalate exposure, while others used 1–4 urine samples. Concentrations of phthalate metabolites varied substantially, and the levels in serum were greatly lower than those in urine. These studies observed no interstudy or intrastudy consistency for association between phthalates and GMS in pregnant women cross-sectionally or longitudinally, regardless of phthalates species or GMS indicator. Most reported associations were not significantly different from null result. Besides, positive and negative relationships also existed. The current epidemiological data do not support the hypothesis that prenatal exposure to phthalates increases GMS risk.Funding Information
- 2020 Cultivation Project for Youth Science Fund from the First Affiliated Hospital of Anhui Medical University (2020kj02)
- Clinical Scientific Research Project of Anhui Medical University (2020xkj161)
This publication has 60 references indexed in Scilit:
- Effects of lifestyle modification on metabolic syndrome: a systematic review and meta-analysisBMC Medicine, 2012
- The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and ElaborationPLoS Medicine, 2009
- Endocrine disrupters as obesogensMolecular and Cellular Endocrinology, 2009
- GRADE: an emerging consensus on rating quality of evidence and strength of recommendationsBMJ, 2008
- Characterization of Phthalate Exposure among Pregnant Women Assessed by Repeat Air and Urine SamplesEnvironmental Health Perspectives, 2008
- Metabolism of phthalates in humansMolecular Nutrition & Food Research, 2007
- Urinary Creatinine Concentrations in the U.S. Population: Implications for Urinary Biologic Monitoring MeasurementsEnvironmental Health Perspectives, 2005
- Temporal Variability of Urinary Phthalate Metabolite Levels in Men of Reproductive AgeEnvironmental Health Perspectives, 2004
- Epidemiology of gestational diabetes mellitus and its association with Type 2 diabetesDiabetic Medicine, 2004
- Pregnancy complications and maternal cardiovascular risk: opportunities for intervention and screening?BMJ, 2002