The effector hormones of the hypothalamic-pituitary-adrenal axis neuroendocrine system are the glucocorticoid hormones cortisol and corticosterone.The level of corticosterone, a systemic intercellular signal, changes dynamically with environmental and psychological stressors and predictably varies with time of day. A wide range of physiological and mental health issues are linked to irregularities in the typical HPA axis activity profiles. Despite several investigations that have uncovered molecular, cellular, and systems-level glucocorticoid actions to date, more glucocorticoid actions, and connections with clinical state, need to be discovered. Hypothalamic-pituitary-adrenal (HPA) axis feedback regulation may be compromised due to reduced mineralocorticoid receptor (MR)-mediated feedback in the brain. Medicinal herbs and their compounds have been shown to have a preventative impact against depression through a variety of ways. Medicinal plants can provide fresh ideas for antidepressant medication research.