Relationship between red blood cell membrane disorders and Doppler ultrasound indices of renal blood flow in patients with chronic kidney disease

Abstract

The study aimed to investigate the relationship between red blood cell membrane disorders and Doppler ultrasound indices of renal blood flow in patients with chronic kidney disease (CKD) stages1-2. Methods. The complex clinical, laboratory and instrumental (color duplex Doppler scanning of renal parenchyma vessels) examination was conducted in 131 CKD stage 1-2 patients. Among them, there were 47 patients with pyelonephritis, 48 patients with diabetic nephropathy, and 36 patients with primary glomerulonephritis. Each patients’ group was divided into 2 subgroups: with and without arterial hypertension. Twenty healthy volunteers were also included for the study control. Results. A significant correlation between indices of the erythrocytes morphology and basic Doppler ultrasonography parameters of the kidney vessels circulation, namely a.interlobaris was demonstrated in CKD patients with arterial hypertension. The most significant changes were observed in diabetic patients. Conclusion. The results of our study indicated a high informative value of renal Doppler ultrasonography as a non-invasive technique to diagnose the CKD progression in patients with comorbid hypertension