The Effect of Plantago major Hydroalcoholic Extract on the Healing of Diabetic Foot and Pressure Ulcers: A Randomized Open-Label Controlled Clinical Trial
Open Access
- 19 January 2022
- journal article
- research article
- Published by SAGE Publications in The International Journal of Lower Extremity Wounds
Abstract
Aims: Diabetic foot ulcer (DFU) and pressure ulcer (PU) both are common types of ulcers worldwide. The wound healing effect of Plantago major leaves has been shown in a few animal studies. This study aimed to evaluate the clinical efficacy of P. major hydroalcoholic extract on DFU and PU healing. Methods: In this clinical trial, patients with DFU or PU who met the inclusion criteria were randomly assigned to drug (P. major) or control groups. For patients in the drug group, Plantago extract 10% topical gel was applied on the wound once daily concurrent with dressing and routine wound care for two weeks, while for the control group, an appropriate novel dressing was used along with routine wound care for the same duration. The percentage of wound size reduction at the end of the seventh and 14th days of intervention was recorded and compared between the groups. Results: Fifty and 44 patients in drug and control groups, respectively, completed the interventions. Plantago extract gel significantly resulted in more reduction in the wound size compared to control at the end of the first (64.90 +/- 29.75% vs. 33.11 +/- 26.55%; P < 0.001) and second week (86.85 +/- 24.34% vs. 52.87 +/- 32.41%; P < 0.001). Furthermore, the number of patients with complete wound healing in the drug group (n = 32, 64%) was significantly more than the control group (n = 9, 20.45%; OR: 3.129, 95% CI: 1.685-5.809, P < 0.001). Conclusion: The use of 10% topical gel of P. major leaf extract results in the acceleration of DFU and PU healing.Keywords
This publication has 17 references indexed in Scilit:
- The medicinal potential of plants from the genus Plantago (Plantaginaceae)Industrial Crops and Products, 2016
- Wound Healing: Biologics, Skin Substitutes, Biomembranes and ScaffoldsHealthcare, 2014
- Diabetic foot ulcersJournal of the American Academy of Dermatology, 2014
- Diabetic foot ulcersJournal of the American Academy of Dermatology, 2014
- Effects of Plantago major L. leaf extracts on oral epithelial cells in a scratch assayJournal of Ethnopharmacology, 2012
- Wound Healing Activity ofRubus sanctusSchreber (Rosaceae): Preclinical Study in Animal ModelsEvidence-Based Complementary and Alternative Medicine, 2011
- Effect ofPlantago majoron Burn Wound Healing in RatJournal of Applied Animal Research, 2010
- Evaluation of banana leaf dressing for partial thickness burn woundsBurns, 2003
- Book Review: Role of Superoxide Dismutases in Oxidative Damage and Neurodegenerative DisordersThe Neuroscientist, 2002
- The Dysvascular Foot: A System for Diagnosis and TreatmentFoot & Ankle, 1981