BerEP4 positivity in Merkel cell carcinoma: a potential diagnosis pitfall
- 17 April 2020
- journal article
- letter
- Published by Wiley in Journal of the European Academy of Dermatology and Venereology
- Vol. 34 (11), E707-E709
- https://doi.org/10.1111/jdv.16482
Abstract
Merkel cell carcinoma (MCC) is a primary neuroendocrine carcinoma of the skin with a 5‐year overall survival estimated at 40%1. In 2008, Merkel cell Polyomavirus (MCPyV) integration was identified as the primary oncogenic event of about 80% of MCC cases. Under microscopic examination, MCC appears as a proliferation of basaloid tumor cells invading the dermis and subcutaneous tissues.Keywords
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