Serum High-Sensitivity C-Reactive Protein Levels and the Development of Atrial Fibrillation in a General Japanese Population ― The Hisayama Study ―
Open Access
- 21 July 2021
- journal article
- research article
- Published by Japanese Circulation Society in Circulation Journal
- Vol. 85 (8), 1365-1372
- https://doi.org/10.1253/circj.cj-20-0751
Abstract
Background:Atrial fibrillation (AF) is a common arrhythmia in the elderly, and causes complications such as cardioembolic stroke. Serum high-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, has been reported to be a risk factor for developing AF in Western countries. However, few community-based studies have examined this issue in general Asian populations. Methods and Results:A total of 2,510 community-dwelling Japanese participants aged ≥40 years without a history of AF were divided into 4 groups according to the sex-specific quartiles of serum hs-CRP concentrations (Q1, lowest and Q4, highest) and followed up for 24 years. The hazard ratios and their 95% confidence intervals for the development of AF were estimated using a Cox proportional hazards model. During the follow up, 234 subjects developed AF. The risk of AF increased significantly with elevating serum hs-CRP levels after adjustment for potential confounding factors (hazard ratio [95% confidence interval], Q1, 1.00 [reference]; Q2, 1.26 [0.83–1.92]; Q3, 1.77 [1.18–2.66]; and Q4, 1.89 [1.24–2.86]; P for trend Conclusions:The study findings suggest that elevated serum hs-CRP levels are an independent risk factor for the development of AF in a general Japanese population.Keywords
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