Quantification of Wave Reflection in the Human Umbilical Artery From Asynchronous Doppler Ultrasound Measurements
- 28 October 2020
- journal article
- research article
- Published by Institute of Electrical and Electronics Engineers (IEEE) in IEEE Transactions on Medical Imaging
- Vol. 39 (11), 3749-3757
- https://doi.org/10.1109/tmi.2020.3004511
Abstract
Elevated umbilical artery pulsatility is a widely used biomarker for placental pathology leading to intra-uterine growth restriction and, in severe cases, still-birth. It has been hypothesized that placental pathology modifies umbilical artery pulsatility by altering the degree to which the pulse pressure wave, which originates from the fetal heart, is reflected from the placental vasculature to interfere with the incident wave. Here we present a method for estimating the reflected pulse wave in the umbilical artery of human fetuses using asynchronously acquired Doppler ultrasound measurements from the two ends of the umbilical cord. This approach assumes non-dispersive and loss-less propagation of the waves along the artery and models the reflection process as a linear system with a parameterized impulse response. Model parameters are determined from the measured Doppler waveforms by constrained optimization. Velocity waveforms were obtained from 142 pregnant volunteers where 123 met data quality criteria in at least one umbilical artery. The reflection model was consistent with the measured waveforms in 183 of 212 arteries that were analyzed. The analysis method was validated by applying it to simulated datasets and comparing solutions to ground-truth. With measurement noise levels typical of clinical ultrasound, parameters describing the reflected wave were accurately determined.Funding Information
- Eunice Kennedy Shriver National Institute of Child Health and Human Development of Health (U01-HD-087177-01)
This publication has 35 references indexed in Scilit:
- Umbilical Coiling Index as a Marker of Perinatal Outcome: An Analytical StudyObstetrics and Gynecology International, 2012
- Intrauterine growth restriction: new concepts in antenatal surveillance, diagnosis, and managementAmerican Journal of Obstetrics and Gynecology, 2011
- Fetal umbilical artery Doppler to predict compromise of fetal/neonatal wellbeing in a high‐risk population: systematic review and bivariate meta‐analysisUltrasound in Obstetrics & Gynecology, 2011
- A critical appraisal of the use of umbilical artery Doppler ultrasound in high‐risk pregnancies: use of meta‐analyses in evidence‐based obstetricsUltrasound in Obstetrics & Gynecology, 2001
- Algorithm 733: TOMP–Fortran modules for optimal control calculationsACM Transactions on Mathematical Software, 1994
- An experimental comparison of different methods of measuring wave propagation in viscoelastic tubesJournal of Biomechanics, 1994
- Analysis of all possible combinations of four measurements determining true propagation in arteriesJournal of Biomedical Engineering, 1993
- Linear and nonlinear one-dimensional models of pulse wave transmission at high Womersley numbersJournal of Biomechanics, 1989
- An efficient method for finding the minimum of a function of several variables without calculating derivativesThe Computer Journal, 1964
- An Experimental Determination of the Propagation of Fluid Oscillations in a Tube with a Visco-elastic Wall; together with an Analysis of the Characteristics Required in an Electrical AnaloguePhysics in Medicine & Biology, 1959