Rethinking Measurement Standards of Autism Symptomology in Adolescents with Fragile X Syndrome
- 6 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Autism and Developmental Disorders
- Vol. 51 (12), 4520-4533
- https://doi.org/10.1007/s10803-021-04892-2
Abstract
Accurate representation of autism spectrum disorder (ASD) in fragile X syndrome (FXS) is necessary for the field. We examined classifications of ASD using three approaches—Autism Diagnostic Observation Schedule (ADOS-2; Lord et al. 2012), Childhood Autism Rating Scale (CARS2-ST; Schopler et al. 2010), and Vineland Adaptive Behavior Scales (VABS-II; Sparrow et al. 2005)—in 45 adolescents with FXS. Maladaptive items from the VABS-II plus a maternal interview were matched with Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5; American Psychiatric Association 2013) criteria for ASD. Results indicated discrepant classifications. The ADOS-2 yielded the highest rate of comorbid autism (71%); CARS2-ST and VABS-II/DSM-5 yielded lower rates (38% and 42%, respectively). A singular measure of autism symptomology is insufficient to characterize autism in FXS.Keywords
Funding Information
- National Institute of Child Health and Human Development (R01 HD084563)
- National Institute on Deafness and Other Communication Disorders (T32 DC000052)
This publication has 31 references indexed in Scilit:
- Diagnostic Evaluation of Autism Spectrum DisordersPediatric Clinics of North America, 2012
- Clinical assessment of DSM-IV anxiety disorders in fragile X syndrome: prevalence and characterizationJournal of Neurodevelopmental Disorders, 2010
- Autism Spectrum Disorder in Children and Adolescents With Fragile X Syndrome: Within-Syndrome Differences and Age-Related ChangesAmerican Journal on Intellectual and Developmental Disabilities, 2010
- Maternal Responsivity Predicts Language Development in Young Children With Fragile X SyndromeAmerican Journal on Intellectual and Developmental Disabilities, 2010
- Developmental Trajectories of Young Girls With Fragile X SyndromeAmerican Journal on Intellectual and Developmental Disabilities, 2009
- Language development and fragile X syndrome: Profiles, syndrome‐specificity, and within‐syndrome differencesMental Retardation and Developmental Disabilities Research Reviews, 2007
- Autistic behavior in children with fragile X syndrome: Prevalence, stability, and the impact of FMRPAmerican Journal of Medical Genetics Part A, 2006
- Cognitive, language and social‐cognitive skills of individuals with fragile X syndrome with and without autismJournal of Intellectual Disability Research, 2006
- Specific Genetic Disorders and Autism: Clinical Contribution Towards their IdentificationJournal of Autism and Developmental Disorders, 2005
- Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndromeCell, 1991