Low prenatal detection rate of valvar pulmonary stenosis: What are we missing?
- 1 July 2020
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 40 (8), 966-971
- https://doi.org/10.1002/pd.5715
Abstract
Objectives Critical pulmonary stenosis (PS) and pulmonary atresia with intact ventricular septum (PAIVS) require urgent neonatal intervention. Since PS may be more insidious than PAIVS during gestation, we hypothesized that neonates with PS would have lower rates of prenatal detection than PAIVS. Methods We performed a retrospective chart review of all neonates who underwent diagnostic or interventional cardiac catheterization between 2000 and 2014 for critical PS or PAIVS. The rates of prenatal diagnosis were calculated for PS and PAIVS. Prenatal and postnatal echocardiographic data were reviewed. Results 178 patients met inclusion criteria: 91 with critical PS and 87 with PAIVS. The prenatal diagnosis rate for critical PS was lower than for PAIVS at 37% (34/91) vs 60% (52/87) (P = .003). At the time of diagnosis at a median gestational age of 25 weeks, the median TV z-score for patients with critical PS was larger than in PAIVS (-0.15 vs -3.0 P = .004). Conclusion Critical PS had a lower prenatal detection rate than PAIVS, likely due to a relatively normal 4-chamber view at the time of routine second trimester screening in patients with PS. Color flow Doppler of the outflow tracts may improve detection, since outflow tracts may appear normal by 2D imaging.This publication has 26 references indexed in Scilit:
- Pulmonary atresia/critical stenosis with intact ventricular septum: prediction of outcome in the second trimester of pregnancyPrenatal Diagnosis, 2011
- Prenatal ultrasound screening of congenital heart disease in an unselected national population: a 21-year experienceHeart, 2010
- Prenatal Detection of Congenital Heart DiseaseThe Journal of Pediatrics, 2009
- Morphologic and Functional Predictors of Eventual Circulation in the Fetus With Pulmonary Atresia or Critical Pulmonary Stenosis With Intact SeptumJournal of the American College of Cardiology, 2008
- Echocardiographic Predictors of Outcome in Fetuses with Pulmonary Atresia with Intact Ventricular SeptumJournal of the American Society of Echocardiography, 2006
- Prevalence of congenital heart diseaseAmerican Heart Journal, 2004
- Indications for fetal echocardiography from a tertiary‐care obstetric sonography practiceJournal of Clinical Ultrasound, 2004
- Pulmonary stenosis and atresia with intact ventricular septum during prenatal lifeUltrasound in Obstetrics & Gynecology, 2003
- Pulmonary Atresia With Intact Ventricular SeptumCirculation, 1998
- Extended fetal echocardiographic examination for detecting cardiac malformations in low risk pregnancies.BMJ, 1992