Can the CRP/albumin Ratio be Used as a New Indicator of Activation in Patients with Uveitis?
- 4 July 2021
- journal article
- research article
- Published by Informa UK Limited in Ocular Immunology and Inflammation
- Vol. 29 (5), 1017-1022
- https://doi.org/10.1080/09273948.2020.1714061
Abstract
Purpose: To evaluate whether the C-reactive protein (CRP)/albumin ratio (CAR) in patients with uveitis during an attack is a marker that can give information about the activity, severity and prognosis of the disease. Methods: This study included 35 patients with an uveitis attack and 35 healthy volunteers. The localization and severity of uveitis were recorded. Patients' complete blood count (CBC) during the attack, CRP, CAR, erythrocyte sedimentation rate(ESR), neutrophil/lymphocyte ratio(NLR), and platelet/lymphocyte ratio(PLR) were recorded. Results: The mean age was 34.1 +/- 12.5 years for the 35 uveitis cases and 30.1 +/- 4.1 years for the healthy volunteers. CRP and CAR were significantly higher in uveitis patients (p = .015 and 0.011, respectively). While CRP and CAR were significantly higher in severe anterior uveitis than mild anterior uveitis (p = .036 and 0.022, respectively), only CAR was significantly higher in severe posterior and panuveitis than mild ones(p = .017). Conclusion: CAR may be an important parameter in determining the activation of the uveitis.Keywords
Funding Information
- not-for-profit sector
This publication has 38 references indexed in Scilit:
- C-Reactive Protein/Albumin Ratio Predicts 90-Day Mortality of Septic PatientsPLOS ONE, 2013
- Prognostic factors of mortality in patients with community-acquired bloodstream infection with severe sepsis and septic shockJournal of Critical Care, 2010
- The Epidemiology of Uveitis in Developing CountriesInternational Ophthalmology Clinics, 2010
- Frequency and clinical features of intraocular inflammation in TokyoClinical & Experimental Ophthalmology, 2009
- Evaluation of a modified early warning system for acute medical admissions and comparison with C-reactive protein/albumin ratio as a predictor of patient outcomeClinical Medicine, 2009
- Population‐based prevalence study of Behçet's disease: Differences by ethnic origin and low variation by age at immigrationArthritis & Rheumatism, 2008
- Procalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome severity in critically ill childrenIntensive Care Medicine, 2007
- Standardization of Uveitis Nomenclature for Reporting Clinical Data. Results of the First International WorkshopAmerican Journal of Ophthalmology, 2005
- Albumin Concentrations Are Primarily Determined by the Body Cell Mass and the Systemic Inflammatory Response in Cancer Patients With Weight LossNutrition and Cancer, 2001
- Standardizatlon of Vitreal inflammatory Activity in Intermediate and Posterior UveitisOphthalmology, 1985