The Role of Exosomes in the Pathophysiology of Chronic Rhinosinusitis
Open Access
- 28 January 2022
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Cellular and Infection Microbiology
- Vol. 11, 812920
- https://doi.org/10.3389/fcimb.2021.812920
Abstract
Non-invasive biomarker analysis has made repetitive and painless sampling over time possible. Exosomes are being released from a parent cell and their cargo mirrors the cell micromilieu of the parent cell. Therefore, exosomes are promising surrogates for their parent cells. That is also why exosomes provide an improved signal-to-noise ratio. Current studies have identified valid non-invasive biomarkers that may be able to monitor disease severity. Exosomes are suggested to play an important role in interepithelial communication and are suggested to play a role in the initiation and maintenance of inflammation in CRS. They are, however, also involved simultaneously in several immunological processes including immune protection and immunosuppression. As the isolation of exosomes is time-consuming their value in everyday routine diagnostics has yet to be determined.This publication has 46 references indexed in Scilit:
- Increased expression of factor XIII-A in patients with chronic rhinosinusitis with nasal polypsJournal of Allergy and Clinical Immunology, 2013
- Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through METNature Medicine, 2012
- Regional expression of epithelial MDR1/P‐glycoprotein in chronic rhinosinusitis with and without nasal polyposisInternational Forum of Allergy & Rhinology, 2011
- Health state utility values in patients undergoing endoscopic sinus surgeryThe Laryngoscope, 2011
- Exosomes – vesicular carriers for intercellular communicationCurrent Opinion in Cell Biology, 2009
- Microvesicles: Messengers and mediators of tumor progressionCell Cycle, 2009
- Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsNature, 2007
- Discovery of Urinary BiomarkersMolecular & Cellular Proteomics, 2006
- Autocrine, paracrine and juxtacrine signaling by EGFR ligandsCellular Signalling, 2005
- Clinical Outcomes in Patients With Chronic SinusitisThe Laryngoscope, 2000