Design of 3‐aminophenol‐grafted polymer‐modified zinc sulphide nanoparticles as drug delivery system
Open Access
- 11 June 2021
- journal article
- research article
- Published by Institution of Engineering and Technology (IET) in IET Nanobiotechnology
- Vol. 15 (8), 664-673
- https://doi.org/10.1049/nbt2.12063
Abstract
Zinc sulphide (ZnS) nanoparticles were synthesized by the coprecipitation method. The ZnS nanoparticle surface was polymerized with allyl glycidyl ether (AGE), and 3-aminophenol was then deposited as a ligand on nanosorbent. The modified nanosorbent was investigated with Fourier transform infrared spectroscopy and thermogravimetric analysis. The particle size of the modified nanosorbent was studied with scanning electron microscopy. Some characteristic factors of the adsorption process such as pH and time were investigated for famotidine using the modified nanosorbent. The equilibrium adsorption study of famotidine by 3-aminophenol-grafted AGE/ZnS was analysed by adsorption isotherms of the Langmuir, Freundlich, and Temkin models. The famotidine-releasing process was investigated in simulated biological fluids (intestinal fluid at pH of 7.4 and gastric fluid at pH of 1.2) and demonstrated 65% and 73% famotidine release during periods of 30 h (pH = 7.4) and 60 min (pH = 1.2), respectively. These results reveal the optimal performance of 3-aminophenol-grafted AGE/ZnS for sustained drug delivery.This publication has 36 references indexed in Scilit:
- Synthesis and characterization of fluorescent chitosan–ZnSe/ZnS nanoparticles for potential drug carriersRSC Advances, 2015
- Synthesis of chitosan-g-poly(acrylamide)/ZnS nanocomposite for controlled drug delivery and antimicrobial activityInternational Journal of Biological Macromolecules, 2015
- Polymer brushes containing thermosensitive and functional groups grafted onto magnetic nano-particles for interaction and extraction of famotidine in biological samplesInternational Journal of Pharmaceutics, 2014
- Preparation and characterization of iminodiacetic acid: magnetite nano-particles as a novel famotidine carrier substrate for sustained drug releaseMonatshefte für Chemie / Chemical Monthly, 2014
- Silica nanohybrids integrated with CuInS2/ZnS quantum dots and magnetite nanocrystals: multifunctional agents for dual-modality imaging and drug deliveryJournal of Materials Chemistry, 2011
- Glycopolypeptide-encapsulated Mn-doped ZnS quantum dots for drug delivery: Fabrication, characterization, and in vitro assessmentColloids and Surfaces B: Biointerfaces, 2011
- Enhancement of the Aqueous Solubility and Masking the Bitter Taste of Famotidine Using Drug/SBE-β-CyD/Povidone K30 Complexation ApproachJournal of Pharmaceutical Sciences, 2010
- A study of carboxylic-modified mesoporous silica in controlled delivery for drug famotidineJournal of Solid State Chemistry, 2006
- Pore- and Solid-Diffusion Kinetics in Fixed-Bed Adsorption under Constant-Pattern ConditionsIndustrial & Engineering Chemistry Fundamentals, 1966
- THE ADSORPTION OF GASES ON PLANE SURFACES OF GLASS, MICA AND PLATINUM.Journal of the American Chemical Society, 1918