Background: “Chronic Kidney Disease” also known as a chronic renal failure, is one of the major health problems today. And infection is the second leading cause of morbidity and mortality in patients with chronic kidney disease, contributing around 30–36% of deaths among patients on dialysis. Overall, this condition is a threat to the life of the patients, hence to improve in the patient’s condition on dialysis and renal replacement therapy is a must. Here, early vaccination becomes must as primary treatment modalities to prevent the patients from communicable diseases like Hepatitis-B, Influenza, Pneumococcal diseases. Aim: To evaluate the effectiveness of the awareness program on selected vaccinations among chronic kidney disease patients. Methodology: Quasi experimental one group pre-test post-test research design will be used in this study and samples will be chronic kidney disease patients. Non probability purposive sampling technique will be used to select the samples. This research study included 100 chronic kidney disease patients of selected hospitals in Vidarbha region. Samples must select according to requirements for inclusion and exclusion criteria. For this study, Age between 18 to 65 years above, both male and female, Chronic kidney disease patients attending Nephrology and Medicine OPD/IPD and admitted patients in selected hospitals in Vidarbha region, able to read and write Marathi or Hindi, Willing to participate in study, available during data collection. Expected Results: 1. To access this information for educating and change the attitude of patients regarding selected vaccination among chronic kidney disease patients. And understand the importance of vaccination before the onset of dialysis and renal transplantation. Conclusion: Conclusion will be drawn from the statistical analysis.