Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients
Open Access
- 16 May 2020
- journal article
- research article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 21 (10), 3532
- https://doi.org/10.3390/ijms21103532
Abstract
Very few data are reported in the literature on the association between elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and prognosis in advanced colorectal cancer. Moreover, there is no information available in relation to the response to antiangiogenic treatment. We analyzed EMAST and vascular endothelial growth factor-B (VEGF-B) microsatellite status, together with standard microsatellite instability (MSI), in relation to prognosis in 141 patients with metastatic colorectal cancer (mCRC) treated with chemotherapy (CT) alone (n = 51) or chemotherapy with bevacizumab (B) (CT + B; n = 90). High MSI (MSI-H) was detected in 3% of patients and was associated with progression-free survival (PFS; p = 0.005) and overall survival (OS; p < 0.0001). A total of 8% of cases showed EMAST instability, which was associated with worse PFS (p = 0.0006) and OS (p < 0.0001) in patients treated with CT + B. A total of 24.2% of patients showed VEGF-B instability associated with poorer outcome in (p = 0.005) in the CT arm. In conclusion, our analysis indicated that EMAST instability is associated with worse prognosis, particularly evident in patients receiving CT + B.This publication has 50 references indexed in Scilit:
- Oxidative Stress Induces Nuclear-to-Cytosol Shift of hMSH3, a Potential Mechanism for EMAST in Colorectal Cancer CellsPLOS ONE, 2012
- Association Between Recurrent Metastasis From Stage II and III Primary Colorectal Tumors and Moderate Microsatellite InstabilityGastroenterology, 2012
- The SNP rs961253 in 20p12.3 Is Associated with Colorectal Cancer Risk: A Case-Control Study and a Meta-Analysis of the Published LiteraturePLOS ONE, 2012
- Signal Transduction by Vascular Endothelial Growth Factor ReceptorsCold Spring Harbor Perspectives in Medicine, 2012
- Microsatellite Alterations at Selected Tetranucleotide Repeats Are Associated With Morphologies of Colorectal NeoplasiasGastroenterology, 2010
- Relationship of EMAST and Microsatellite Instability Among Patients with Rectal CancerJournal of Gastrointestinal Surgery, 2010
- Microsatellite instability in colorectal cancer—the stable evidenceNature Reviews Clinical Oncology, 2010
- Deficient mismatch repair system in patients with sporadic advanced colorectal cancerBritish Journal of Cancer, 2009
- Authors' replyGut, 2006
- Characterizing genetically stable and unstable gastric cancers by microsatellites and array comparative genomic hybridizationCancer Genetics and Cytogenetics, 2006