Lipid droplets and autophagy—links and regulations from yeast to humans
Open Access
- 31 January 2021
- journal article
- research article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 122 (6), 602-611
- https://doi.org/10.1002/jcb.29889
Abstract
Recent advances in the yeast Saccharomyces cerevisiae and higher eukaryotes have been increasingly connecting lipid droplet (LD) dynamics to the regulation of autophagy. In this review we will discuss implications that connect LD de novo synthesis and LD mobilization to autophagy and how autophagy is regulated by these mechanisms. Elucidating these connections might pose a chance to further understand autophagy induction and membrane biogenesis for the growing autophagosome under different conditions. Increasing our understanding of these mechanisms might provide a chance to understand several conditions that might be related to LD dysregulation and, possibly, as a consequence of this, dysregulation of autophagy.Keywords
Funding Information
- Deutsche Forschungsgemeinschaft (SFB 1177)
This publication has 79 references indexed in Scilit:
- Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid dropletsMolecular Biology of the Cell, 2012
- Autophagy and Lipid Metabolism Coordinately Modulate Life Span in Germline-less C. elegansCurrent Biology, 2011
- Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy BalanceCell Metabolism, 2011
- Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid LipaseCell Metabolism, 2011
- The Putative Saccharomyces cerevisiae Hydrolase Ldh1p Is Localized to Lipid DropletsEukaryotic Cell, 2011
- Loss-of-Function Mutations in RAB18 Cause Warburg Micro SyndromeAmerican Journal of Human Genetics, 2011
- Hallmarks of Cancer: The Next GenerationCell, 2011
- A phosphorylation-regulated amphipathic helix controls the membrane translocation and function of the yeast phosphatidate phosphataseProceedings of the National Academy of Sciences of the United States of America, 2010
- Autophagy regulates lipid metabolismNature, 2009
- The Hallmarks of CancerCell, 2000