The Role of Rho GTPases in VEGF Signaling in Cancer Cells
Open Access
- 16 April 2020
- journal article
- review article
- Published by Hindawi Limited in Analytical Cellular Pathology
- Vol. 2020, 1-11
- https://doi.org/10.1155/2020/2097214
Abstract
Vascular endothelial growth factors (VEGFs) consist of five molecules (VEGFA through D as well as placental growth factor) which are crucial for regulating key cellular and tissue functions. The role of VEGF and its intracellular signaling and downstream molecular pathways have been thoroughly studied. Activation of VEGF signal transduction can be initiated by the molecules' binding to two classes of transmembrane receptors: (1) the VEGF tyrosine kinase receptors (VEGF receptors 1 through 3) and (2) the neuropilins (NRP1 and 2). The involvement of Rho GTPases in modulating VEGFA signaling in both cancer cells and endothelial cells has also been well established. Additionally, different isoforms of Rho GTPases, namely, RhoA, RhoC, and RhoG, have been shown to regulate VEGF expression as well as blood vessel formation. This review article will explore how Rho GTPases modulate VEGF signaling and the consequences of such interaction on cancer progression.This publication has 129 references indexed in Scilit:
- Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growthThe Journal of Experimental Medicine, 2012
- Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1Published by Elsevier BV ,2012
- Vascular Endothelial Growth Factor A (VEGF-A) Induces Endothelial and Cancer Cell Migration through Direct Binding to Integrin α9β1Published by Elsevier BV ,2011
- GIPC1 Interacts with MyoGEF and Promotes MDA-MB-231 Breast Cancer Cell InvasionPublished by Elsevier BV ,2010
- Cell adhesion: integrating cytoskeletal dynamics and cellular tensionNature Reviews Molecular Cell Biology, 2010
- The Regulation of Vascular Endothelial Growth Factor-induced Microvascular Permeability Requires Rac and Reactive Oxygen SpeciesPublished by Elsevier BV ,2009
- ABL2/ARG Tyrosine Kinase Mediates SEMA3F-induced RhoA Inactivation and Cytoskeleton Collapse in Human Glioma CellsPublished by Elsevier BV ,2008
- Rac Activation and Inactivation Control Plasticity of Tumor Cell MovementCell, 2008
- Clinical translation of angiogenesis inhibitorsNature Reviews Cancer, 2002
- Patterns and Emerging Mechanisms of the Angiogenic Switch during TumorigenesisCell, 1996