Changes to the Oligosaccharide Profile of Bovine Milk at the Onset of Lactation
Open Access
- 1 December 2020
- Vol. 1 (3), 284-296
- https://doi.org/10.3390/dairy1030019
Abstract
Numerous bioactive components exist in human milk including free oligosaccharides, which represent some of the most important, and provide numerous health benefits to the neonate. Considering the demonstrated value of these compounds, much interest lies in characterising structurally similar oligosaccharides in the dairy industry. In this study, the impacts of days post-parturition and parity of the cows on the oligosaccharide and lactose profiles of their milk were evaluated. Colostrum and milk samples were obtained from 18 cows 1–5 days after parturition. Three distinct phases were identified using multivariate analysis: colostrum (day 0), transitional milk (days 1–2) and mature milk (days 3–5). LS-tetrasaccharide c, lacto-N-neotetraose, disialyllacto-N-tetraose, 3’-sial-N-acetyllactosamine, 3’-sialyllactose, lacto-N-neohexaose and disialyllactose were found to be highly affiliated with colostrum. Notably, levels of lactose were at their lowest concentration in the colostrum and substantially increased 1-day post-parturition. The cow’s parity was also shown to have a significant effect on the oligosaccharide profile, with first lactation cows containing more disialyllacto-N-tetraose, 6’-sialyllactose and LS-tetrasaccharide compared to cows in their second or third parity. Overall, this study identifies key changes in oligosaccharide and lactose content that clearly distinguish colostrum from transitional and mature milk and may facilitate the collection of specific streams with divergent biological functions.Keywords
This publication has 73 references indexed in Scilit:
- Fucosylated but Not Sialylated Milk Oligosaccharides Diminish Colon Motor ContractionsPLOS ONE, 2013
- Colostrum - Its Composition, Benefits As A Nutraceutical : A ReviewCurrent Research in Nutrition and Food Science Journal, 2013
- Exposure of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional ResponsePLOS ONE, 2013
- Natural Variability in Bovine Milk Oligosaccharides from Danish Jersey and Holstein-Friesian BreedsJournal of Agricultural and Food Chemistry, 2012
- Changes in composition of colostrum of Egyptian buffaloes and Holstein cowsBMC Veterinary Research, 2012
- Method for milk oligosaccharide profiling by 2-aminobenzamide labeling and hydrophilic interaction chromatographyGlycobiology, 2011
- Potential impact of the non‐human sialic acid N‐glycolylneuraminic acid on transplant rejection riskXenotransplantation, 2011
- Development of an Annotated Library of Neutral Human Milk OligosaccharidesJournal of Proteome Research, 2010
- Recent advances in exploiting goat's milk: Quality, safety and production aspectsSmall Ruminant Research, 2010
- Permeate from cheese whey ultrafiltration is a source of milk oligosaccharidesInternational Dairy Journal, 2009