Mucin-Grafted Polyethylene Glycol Microparticles Enable Oral Insulin Delivery for Improving Diabetic Treatment
Open Access
- 10 April 2020
- journal article
- research article
- Published by MDPI AG in Applied Sciences
- Vol. 10 (8), 2649
- https://doi.org/10.3390/app10082649
Abstract
In this study, different ratios of mucin-grafted polyethylene-glycol-based microparticles were prepared and evaluated both in vitro and in vivo as carriers for the oral delivery of insulin. Characterization measurements showed that the insulin-loaded microparticles display irregular porosity and shape. The encapsulation efficiency and loading capacity of insulin were >82% and 18%, respectively. The release of insulin varied between 68% and 92% depending on the microparticle formulation. In particular, orally administered insulin-loaded microparticles resulted in a significant fall of blood glucose levels, as compared to insulin solution. Subcutaneous administration showed a faster, albeit not sustained, glucose fall within a short time as compared to the polymeric microparticle-based formulations. These results indicate the possible oral delivery of insulin using this combination of polymers.This publication has 33 references indexed in Scilit:
- Eudragit-coated aceclofenac-loaded pectin microspheres in chronopharmacological treatment of rheumatoid arthritisDrug Delivery, 2013
- Insulin therapies: Current and future trends at dawnWorld Journal of Diabetes, 2013
- Eudragit S-100 coated sodium alginate microspheres of naproxen sodium: Formulation, optimization and in vitro evaluation / Alginatne mikrosfere naproksen natrija obložene Eudragitom S-100: Priprava, optimizacija i in vitro vrednovanjeActa Pharmaceutica, 2012
- IDF Diabetes Atlas: Global estimates of the prevalence of diabetes for 2011 and 2030Diabetes Research and Clinical Practice, 2011
- Design and evaluation of novel pH-sensitive chitosan nanoparticles for oral insulin deliveryEuropean Journal of Pharmaceutical Sciences, 2011
- Formulation and characterization of an oily-based system for oral delivery of insulinEuropean Journal of Pharmaceutics and Biopharmaceutics, 2009
- Formulation and in vitro evaluation of a PEGylated microscopic lipospheres delivery system for ceftriaxone sodiumDrug Delivery, 2009
- Preparation and evaluation of mucinated sodium alginate microparticles for oral delivery of insulinEuropean Journal of Pharmaceutics and Biopharmaceutics, 2008
- Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approachJournal of Controlled Release, 2006
- Practical approaches to insulin therapy for type 2 diabetes mellitus with premixed insulin analoguesClinical Therapeutics, 2005