HPLC-MS method development and validation for simultaneous quantitation of GZK-111 and CPG compounds in rat plasma
Open Access
- 28 April 2020
- journal article
- Published by Publishing House OKI in Pharmacokinetics and Pharmacodynamics
- No. 4,p. 28-36
- https://doi.org/10.37489/2587-7836-2019-4-28-36
Abstract
The technique of quantitative determination of GZK-111 and CPG compounds in rat blood plasma has been developed. The analysis was carried out using the combined method of high-performance liquid chromatography with mass spectrometric detection. The method was linear in the concentration range of 25-1000 ng/ml for both compounds. Percentage of GZK-111 extraction from rat blood plasma was 57.8 %. The lower limit of detection for GZK- 111 compound was 25 ng/ml. Percentage of extraction of CPG compound was 42.5 %. The lower limit of detection of CPG compound was also 25 ng/ml.Keywords
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