Pyroptosis and Its Regulation in Diabetic Cardiomyopathy
Open Access
- 25 January 2022
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Physiology
- Vol. 12, 791848
- https://doi.org/10.3389/fphys.2021.791848
Abstract
Diabetic cardiomyopathy (DbCM) is a prevalent disease, characterized by contractile dysfunction and left ventricular hypertrophy. Patients with DbCM have high morbidity and mortality worldwide. Recent studies have identified that pyroptosis, a kind of cell death, could be induced by hyperglycemia involved in the formation of DbCM. This review summarizes the regulatory mechanisms of pyroptosis in DbCM, including NOD-like receptor3, AIM2 inflammasome, long non-coding RNAs, microRNAs, circular RNA, autophagy, and some drugs.Keywords
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