Sebaceous Carcinoma Epidemiology and Genetics: Emerging Concepts and Clinical Implications for Screening, Prevention, and Treatment
- 9 September 2020
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 27 (2), 389-393
- https://doi.org/10.1158/1078-0432.ccr-20-2473
Abstract
Sebaceous carcinoma is an aggressive skin cancer with a 5-year overall survival rate of 78% for localized/regional disease and 50% for metastatic disease. The incidence of this cancer has been increasing in the United States for several decades, but the underlying reasons for this increase are unclear. In this article, we review the epidemiology and genetics of sebaceous carcinoma, including recent population data and tumor genomic analyses that provide new insights into underlying tumor biology. We further discuss emerging evidence of a possible viral etiology for this cancer. Lastly, we review the clinical implications of recent advances in sebaceous carcinoma research for screening, prevention, and treatment.Keywords
Funding Information
- HHS | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (Intramural Research Funding from Division of Cancer Epidemiology and Genetics,NCI,NIH)
- HHS | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (Intramural Research Funding from Division of Cancer Epidemiology and Genetics,NCI,NIH)
- HHS | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (Intramural Research Funding from Division of Cancer Epidemiology and Genetics,NCI,NIH)
- HHS | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (Intramural Research Funding from Division of Cancer Epidemiology and Genetics,NCI,NIH)
- HHS | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (Intramural Research Funding from Division of Cancer Epidemiology and Genetics,NCI,NIH)
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