Pathological and Prognostic Indications of the mdig Gene in Human Lung Cancer
Open Access
- 11 January 2021
- journal article
- research article
- Published by Cell Physiol Biochem Press GmbH and Co KG in Cellular Physiology and Biochemistry
- Vol. 55 (S2), 13-28
- https://doi.org/10.33594/000000322
Abstract
Background/Aims: The mineral-dust-induced gene mdig is a lung-cancer-associated oncogene. The focus of this study is to evaluate the expression status of mdig in lung cancer and to assess its influence in predicting the patient's overall survival. Methods: Using highdensity tissue microarrays and clinical samples of synchronous multiple primary lung cancer (SMPLC), we investigated the expression of mdig through immunohistochemistry and utilized the open-access lung cancer patient databases containing genomic and transcriptomic data from the UCSC Xena and TCGA web platforms to determine the prognostic values of mdig expression status among different subtypes of lung cancer. Results: mdig is upregulated in smokers and in lung squamous cell carcinoma. High mdig expression predicted poor overall survival in lung squamous cell carcinoma and female smokers. Among tumor tissues from SMPLC patients, we not only unraveled the highest positive rate of mdig expression, but also revealed a unique cytoplasmic, rather than nuclear localization of mdig protein. Furthermore, by inspecting some pathological but not cancerous lung tissues, we believe that mdig is required for the transformation of non-cancerous lung cells to the fully-fledged cancer cells. Conclusion: These data suggested that mdig is involved in various stages of lung carcinogenesis, possibly through the epigenetic regulation on some critical cancer-associated genes, and increased mdig expression is an important prognostic factor for some types of lung cancer. (c) 2021 The Author(s). Published by Cell Physiol Biochem Press GmbH&Co. KGThis publication has 42 references indexed in Scilit:
- Jetset: selecting the optimal microarray probe set to represent a geneBMC Bioinformatics, 2011
- A Grading System of Lung Adenocarcinomas Based on Histologic Pattern is Predictive of Disease Recurrence in Stage I TumorsThe American Journal of Surgical Pathology, 2010
- TH2 bias: Mina tips the balanceNature Immunology, 2009
- Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3Cell Cycle, 2009
- Comparison of aspects of smoking among the four histological types of lung cancerTobacco Control, 2008
- Global loss of imprinting leads to widespread tumorigenesis in adult miceCancer Cell, 2005
- A comprehensive catalog of CpG islands methylated in human lung adenocarcinomas for the identification of tumor suppressor genesOncogene, 2002
- Aberrant CpG-island methylation has non-random and tumour-type–specific patternsNature Genetics, 2000
- Lung Cancer in Patients with Idiopathic Pulmonary Fibrosis.The Tohoku Journal of Experimental Medicine, 1992
- DIFFUSE INTERSTITIAL PULMONARY FIBROSIS AND LUNG CANCERActa Pathologica Japonica, 1987