Potential biomarkers in septic shock besides lactate
- 10 April 2020
- journal article
- review article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 245 (12), 1066-1072
- https://doi.org/10.1177/1535370220919076
Abstract
Elevated lactate has been commonly considered as a biomarker and a useful prognostic tool for resuscitation in septic shock, facilitating physician more rapid intervention and treatment. However, it can be initiated by hypoxia, but persistent hyperlactatemia may not represent persistent hypoxia only. In the article, it is the first time to review potential biomarkers in septic shock from the point of view of energy metabolism including intermediates of TCA cycle, MAS, the NAD+/NADH ratio, NAD+, NADH, malate, and MDH. And the combination of lactate and MDH is also proposed in septic shock for the first time, as MDH in cytoplasm and mitochondria participates in both MAS and TCA cycle for ATP generation. Its feasibility in clinic has been analyzed at the end, although related research is still limited. It is reasonable the combination of lactate and MDH will be more comprehensive to reflex hypoxia in septic shock.Funding Information
- Zhejiang Provincial Natural Science Foundation of China (No. LGD20H150003)
- National Natural Science Foundation of China (No.81772110)
This publication has 60 references indexed in Scilit:
- Biochemical Issues in Estimation of Cytosolic Free NAD/NADH RatioPLOS ONE, 2012
- Induction of Erythroid Differentiation in Human Erythroleukemia Cells by Depletion of Malic Enzyme 2PLOS ONE, 2010
- Oxidation–reduction states of NADH in vivo: From animals to clinical useMitochondrion, 2007
- Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell SurvivalCell, 2007
- Lactate and shock state: the metabolic viewCurrent Opinion in Critical Care, 2006
- Functional Roles of ATP-Binding Residues in the Catalytic Site of Human Mitochondrial NAD(P)+-Dependent Malic EnzymeBiochemistry, 2005
- Developmental regulation and cellular distribution of human cytosolic malate dehydrogenase (MDH1)Journal of Cellular Biochemistry, 2004
- The mature form of imported mitochondrial proteins undergoes conformational changes upon binding to isolated mitochondriaJBIC Journal of Biological Inorganic Chemistry, 1993
- Mitochondrial size distribution analysis in the soleus muscle of trained and aged ratsCellular and Molecular Life Sciences, 1973
- Control of the transport of reducing equivalents across the mitochondrial membrane in perfused rat heartJournal of Molecular and Cellular Cardiology, 1971