Adipsin promotes bone marrow adiposity by priming mesenchymal stem cells
Open Access
- 22 June 2021
- journal article
- research article
- Published by eLife Sciences Publications, Ltd in eLife
Abstract
Marrow adipose tissue (MAT) has been shown to be vital for regulating metabolism and maintaining skeletal homeostasis in the bone marrow (BM) niche. As a reflection of BM remodeling, MAT is highly responsive to nutrient fluctuations, hormonal changes, and metabolic disturbances such as obesity and diabetes mellitus. Expansion of MAT has also been strongly associated with bone loss in mice and humans. However, the regulation of BM plasticity remains poorly understood, as does the mechanism that links changes in marrow adiposity with bone remodeling.Keywords
Funding Information
- National Institutes of Health (T32DK007328)
- National Institutes of Health (F31DK124926)
- National Institutes of Health (R01DK121140)
- National Institutes of Health (R01AR068970)
- National Institutes of Health (R01AR071463)
- National Institutes of Health (R01DK112943)
- National Institutes of Health (R24DK092759)
- National Institutes of Health (P01HL087123)
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