The multifaceted role of vitamin B6 in cancer: Drosophila as a model system to investigate DNA damage
Open Access
- 25 March 2020
- journal article
- review article
- Published by The Royal Society in Open Biology
- Vol. 10 (3), 200034
- https://doi.org/10.1098/rsob.200034
Abstract
A perturbed uptake of micronutrients, such as minerals and vitamins, impacts on different human diseases, including cancer and neurological disorders. Several data converge towards a crucial role played by many micronutrients in genome integrity maintenance and in the establishment of a correct DNA methylation pattern. Failure in the proper accomplishment of these processes accelerates senescence and increases the risk of developing cancer, by promoting the formation of chromosome aberrations and deregulating the expression of oncogenes. Here, the main recent evidence regarding the impact of some B vitamins on DNA damage and cancer is summarized, providing an integrated and updated analysis, mainly centred on vitamin B-6. In many cases, it is difficult to finely predict the optimal vitamin rate that is able to protect against DNA damage, as this can be influenced by a given individual's genotype. For this purpose, a precious resort is represented by model organisms which allow limitations imposed by more complex systems to be overcome. In this review, we show that Drosophila can be a useful model to deeply understand mechanisms underlying the relationship between vitamin B-6 and genome integrity.Funding Information
- Russian Foundation for Basic Researches (Italy-Russia bilateral project (N. 18-54-7812))
- Consiglio Nazionale delle Ricerche (Italy-Russia bilateral project (CUP B86C1700027000)
- Sapienza Università di Roma (Progetto di Ateneo n. RM11916B51484C08)
- Istituto Pasteur Italia - Fondazione Cenci Bolognetti (Research grant “Anna Tramontano” 2018)
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