Thyroid Hormones, Glucocorticoids, Insulin, and Bone
- 1 January 2019
- book chapter
- other
- Published by Springer Science and Business Media LLC
- p. 93-120
- https://doi.org/10.1007/164_2019_314
Abstract
Several endocrine systems have important effects on bone tissue. Thyroid hormones are essential for normal growth and development. Excess of these hormones will result in clinically significant changes that may require intervention. Glucocorticoids also have a marked effect on bone metabolism by several pathways. Their endogenous or exogenous excess will induce pathological processes that might elevate the risk of fractures. Insulin and the carbohydrate metabolism elicit a physiological effect on bone; however, the lack of insulin (type 1 diabetes) or insulin resistance (type 2 diabetes) have deleterious influence on bone tissue.Keywords
This publication has 99 references indexed in Scilit:
- Comparative effects of teriparatide and risedronate in glucocorticoid-induced osteoporosis in men: 18-month results of the EuroGIOPs trialJournal of Bone and Mineral Research, 2013
- The rs4844880 polymorphism in the promoter region of the HSD11B1 gene associates with bone mineral density in healthy and postmenopausal osteoporotic womenSteroids, 2012
- Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanismBone, 2011
- Glucocorticoid dose determines osteocyte cell fateThe FASEB Journal, 2011
- T3 affects expression of collagen I and collagen cross-linking in bone cell culturesBiochemical and Biophysical Research Communications, 2010
- Glucocorticoids Suppress Bone Formation by Attenuating Osteoblast Differentiation via the Monomeric Glucocorticoid ReceptorCell Metabolism, 2010
- Endocrine Regulation of Energy Metabolism by the SkeletonCell, 2007
- COBRA combination therapy in patients with early rheumatoid arthritis: Long‐term structural benefits of a brief interventionArthritis & Rheumatism, 2002
- Follicular cells of the thyroid gland require Pax8 gene functionNature Genetics, 1998
- Circulating Telopeptide Type I Is a Peripheral Marker of Thyroid Hormone Action in Hyperthyroidism and During Levothyroxine Suppressive TherapyThyroid®, 1997